Increased activity of the antioxidants systems modulate the oxidative stress in saliva of toddlers with early childhood caries

Graphical abstract In saliva of children (0–3 years) with severe early childhood caries (S-ECC) total protein levels are higher than in saliva of caries-free children. Oxidative damage, evaluated by TBARS, was reduced in saliva of S-ECC. This alteration was associated to increased total antioxidant...

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Bibliographic Details
Published in:Archives of oral biology 2016-10, Vol.70, p.62-66
Main Authors: da Silva, Priscila Vieira, Troiano, Jéssica Antonini, Nakamune, Ana Cláudia M.S, Pessan, Juliano Pelim, Antoniali, Cristina
Format: Article
Language:English
Subjects:
Advanced Basic Science
Antioxidants - metabolism
Child
Child, Preschool
Children
Dental caries
Dental Caries - enzymology
Dental Caries - metabolism
Dentistry
Enzyme Activation
Female
Humans
Infant
Infant, Newborn
Male
Malondialdehyde - metabolism
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Saliva
Saliva - enzymology
Saliva - metabolism
Superoxide dismutase
Superoxide Dismutase - metabolism
Uric acid
Uric Acid - metabolism
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Summary:Graphical abstract In saliva of children (0–3 years) with severe early childhood caries (S-ECC) total protein levels are higher than in saliva of caries-free children. Oxidative damage, evaluated by TBARS, was reduced in saliva of S-ECC. This alteration was associated to increased total antioxidant capacity (TAC), evaluated by FRAP, in saliva of S-ECC children. Higher superoxide dismutase (SOD) activity and uric acid (UA), the enzymatic and non-enzymatic antioxidant systems respectively, contribute to the reduced levels of oxidative damage in saliva of S-ECC.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2016.06.003