Substantial molecular evolution and mutation rates in prolonged latent Mycobacterium tuberculosis infection in humans

Abstract The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identif...

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Bibliographic Details
Published in:International journal of medical microbiology 2016-11, Vol.306 (7), p.580-585
Main Authors: Lillebaek, Troels, Norman, Anders, Rasmussen, Erik Michael, Marvig, Rasmus L, Folkvardsen, Dorte Bek, Andersen, Åse Bengård, Jelsbak, Lars
Format: Article
Language:English
Subjects:
Evolution, Molecular
Genome sequencing
Genome, Bacterial
Humans
Infectious Disease
Latent infection
Latent Tuberculosis - microbiology
Medical Education
Mutation Rate
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Pathogen evolution
Sequence Analysis, DNA
Within-host evolution
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Summary:Abstract The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identified two confirmed cases, and used whole genome sequencing to investigate the mutational processes that occur over decades in latent Mtb. We found an estimated mutation rate between 0.2 and 0.3 over 33 years, suggesting that latent Mtb accumulates mutations at rates similar to observations from cases of active disease.
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2016.05.017