High serum level of methylglyoxal-derived AGE, Nδ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine, independently relates to renal dysfunction

• Published in: Clinical and experimental nephrology 2017-06, Vol.21 (3), p.398-406
• Main Authors: Ito, Kenji, Sakata, Noriyuki, Nagai, Ryoji, Shirakawa, Jun-ichi, Watanabe, Maho, Mimata, Ayako, Abe, Yasuhiro, Yasuno, Tetsuhiko, Sasatomi, Yoshie, Miyake, Katsuhisa, Ueki, Naoko, Hamauchi, Aki, Nakashima, Hitoshi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers - blood; Chi-Square Distribution; Chromatography, Liquid; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Glycation End Products, Advanced - blood; Humans; Imidazoles - blood; Kidney - physiopathology; Logistic Models; Lysine - analogs & derivatives; Lysine - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Odds Ratio; Original Article; Ornithine - analogs & derivatives; Ornithine - blood; Predictive Value of Tests; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - physiopathology; Tandem Mass Spectrometry; Up-Regulation; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-016-1301-9

Background The dicarbonyl methylglyoxal reacts primarily with arginine residues to form advanced glycation end products, including N δ-(5-hydro-5-methyl-4 -imidazolone-2-yl)-ornithine (MG-H1), which are risk factors for not only diabetic complications but also lifestyle-related disease including renal dysfunction. However, the data on serum level and clinical significance of this substance in chronic kidney disease are limited. Methods Serum levels of MG-H1 and N ε-(carboxymethyl) lysine (CML) in 50 patients with renal dysfunction were measured by liquid chromatography/triple-quadruple mass spectrometry. Results The median serum MG-H1 levels in patients with estimated glomerular filtration rate (eGFR) of ≥30, 15–30, and  0.05). On the other hand, MG-H1 levels in patients with HbA1c of