Coffee intake and the incident risk of cognitive disorders: A dose–response meta-analysis of nine prospective cohort studies

Summary Background & aims Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence o...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2017-06, Vol.36 (3), p.730-736
Main Authors: Wu, Lei, Sun, Dali, He, Yao
Format: Article
Language:English
Subjects:
Alzheimer's disease
Coffee intake
Cognitive disorders
Cognitive impairment
Dementia
Gastroenterology and Hepatology
Meta-analysis
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Summary:Summary Background & aims Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence of coffee drinking and its potential dose–response patterns on the risk of developing cognitive disorders specifically. Methods Two databases (PubMed and Embase) were searched for evidence of cohort studies from inception to February 2016. We used a generic inverse-variance method with a random-effects model to pool the fully adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs). In the dose–response analyses, a generalized least-squares trend estimation model was applied to computing the study-specific slopes. Results Nine prospective cohort studies involving 34,282 participants were included in our study. The duration of follow-up years ranged from 1.3 to 28. Compared with
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2016.05.015