Interaction of resistance training, electroacupuncture and Huang Qi supplementation on skeletal muscle function and GLUT4 protein concentration in rats

ObjectiveTo determine the effects and potential synergy of resistance training (RT), Huang Qi (HQ) herbal supplementation, and electroacupuncture (EA) on skeletal muscle mass, contractile properties, and components of the insulin signalling pathway in healthy Sprague Dawley rats.MethodsFemale Spragu...

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Published in:Acupuncture in medicine : journal of the British Medical Acupuncture Society 2016-10, Vol.34 (5), p.380-385
Main Authors: Lee, Sukho, Kim, Kijeong, Lambrecht, Nathalie J, Hong, Junyoung, Liao, Yi-Hung, Yoon, Aram, Bernard, Jeffrey R
Format: Article
Language:English
Subjects:
Animals
Dietary Supplements
Drugs, Chinese Herbal - therapeutic use
Electroacupuncture - methods
Female
Glucose Transporter Type 4 - blood
Insulin - metabolism
Muscle, Skeletal - physiology
Physical Conditioning, Animal - methods
Physical Conditioning, Animal - physiology
Random Allocation
Rats
Rats, Sprague-Dawley
Resistance Training - methods
Signal Transduction - physiology
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Summary:ObjectiveTo determine the effects and potential synergy of resistance training (RT), Huang Qi (HQ) herbal supplementation, and electroacupuncture (EA) on skeletal muscle mass, contractile properties, and components of the insulin signalling pathway in healthy Sprague Dawley rats.MethodsFemale Sprague Dawley rats were randomly assigned to one of five groups (n=8 each): control (CON), RT only, RT with EA (RT-EA), RT with HQ (RT-HQ), and RT combined with both EA and HQ (RT-EA-HQ). RT was performed using ladder climbing every other day for 8 weeks. Sparse-wave EA was applied for 15 min/day, 3 times/week for 8 weeks. HQ supplementation was provided via oral gavage daily for 8 weeks.ResultsRT significantly increased the muscle mass of the flexor hallucis longus (FHL) compared to CON. The isometric twitch and tetanic tension of the FHL in the RT-EA, RT-HQ, and RT-EA-HQ groups were significantly higher compared to CON and RT groups. RT-EA treatment (with or without HQ) significantly increased GLUT4 protein concentration but had no impact on Akt-2.ConclusionsEA appears to be an effective treatment modality for increasing muscle mass and function when combined with RT. RT-EA may also be an effective method for improving glucose tolerance as a result of increases in GLUT4 protein concentration.
ISSN:0964-5284
1759-9873
DOI:10.1136/acupmed-2015-011028