The severity of ventricular arrhythmia correlates with the extent of myocardial sympathetic denervation, but not with myocardial fibrosis extent in chronic Chagas cardiomyopathy: Chagas disease, denervation and arrhythmia

Background To investigate the correlation between the extent of myocardial sympathetic denervation and fibrosis and the presence of degrees of severity of ventricular arrhythmias in chronic Chagas cardiomyopathy (CCC). Methods Forty-three CCC patients with left ventricular ejection fraction (LVEF) ≥...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nuclear cardiology 2018-02, Vol.25 (1), p.75-83
Main Authors: Gadioli, Leonardo Pippa, Miranda, Carlos Henrique, Pintya, Antonio Osvaldo, de Figueiredo, Alexandre Baldini, Schmidt, André, Maciel, Benedito Carlos, Marin-Neto, José Antonio, Simões, Marcus Vinicius
Format: Article
Language:English
Subjects:
Adult
Aged
Arrhythmias, Cardiac - diagnostic imaging
Cardiology
Chagas Cardiomyopathy - diagnostic imaging
Echocardiography
Electrocardiography
Female
Fibrosis
Heart - diagnostic imaging
Heart Ventricles - diagnostic imaging
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Perfusion Imaging
Myocardium - pathology
Nuclear Medicine
Original Article
Perfusion
Prospective Studies
Radiology
Severity of Illness Index
Sympathectomy
Systole
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background To investigate the correlation between the extent of myocardial sympathetic denervation and fibrosis and the presence of degrees of severity of ventricular arrhythmias in chronic Chagas cardiomyopathy (CCC). Methods Forty-three CCC patients with left ventricular ejection fraction (LVEF) ≥ 35% were divided into three groups: SVT group—presenting Sustained Ventricular Tachycardia (SVT) (n = 15), NSVT group— exhibiting episodes of non-SVT (NSVT) on 24-h Holter monitoring (n = 11), and Control group— exhibiting neither SVT nor episodes of NSVT (n = 17). The patients underwent SPECT imaging for myocardial sympathetic innervation with 123 Iodine-MIBG (MIBG) and myocardial perfusion with 99m Tc-Sestamibi (MIBI) for the evaluation of regional myocardial fibrosis. Results The summed rest perfusion scores were similar in the three groups. The summed difference score between MIBG and MPI images, which evaluated the extent of denervated but viable myocardium, was significantly higher in SVT group (20.0 ± 8.0) as compared with the control group (2.0 ± 5.0, P  
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-016-0556-6