The intraflagellar transport machinery in ciliary signaling

[Display omitted] •The cilium is a nexus for numerous signaling pathways.•Intraflagellar transport (IFT) and BBSome complexes function in ciliary signaling.•The IFT machinery traffics Hedgehog signaling factors. Cilia and flagella on eukaryotic cells are slender microtubule-based projections surroun...

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Bibliographic Details
Published in:Current opinion in structural biology 2016-12, Vol.41, p.98-108
Main Authors: Mourão, André, Christensen, Søren T, Lorentzen, Esben
Format: Article
Language:English
Subjects:
Biological Transport
Cilia - metabolism
Flagella - metabolism
Signal Transduction
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Summary:[Display omitted] •The cilium is a nexus for numerous signaling pathways.•Intraflagellar transport (IFT) and BBSome complexes function in ciliary signaling.•The IFT machinery traffics Hedgehog signaling factors. Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2016.06.009