Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

Control of mRNA translation plays a crucial role in the regulation of gene expression and is critical for cellular homeostasis. Dysregulation of translation initiation factors has been documented in several pathologies including cancer. Aberrant function of translation initiation factors leads to tr...

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Bibliographic Details
Published in:Trends in cell biology 2016-12, Vol.26 (12), p.918-933
Main Authors: Chu, Jennifer, Cargnello, Marie, Topisirovic, Ivan, Pelletier, Jerry
Format: Article
Language:English
Subjects:
Aberration
Angiogenesis
Animals
Cancer
Gene expression
Homeostasis
Humans
Initiation factors
Metastases
Models, Biological
Neoplasms - metabolism
Pathology
Peptide Chain Initiation, Translational
Peptide Initiation Factors - metabolism
Protein biosynthesis
Protein synthesis
translation
translation initiation
translational control
Tumors
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Summary:Control of mRNA translation plays a crucial role in the regulation of gene expression and is critical for cellular homeostasis. Dysregulation of translation initiation factors has been documented in several pathologies including cancer. Aberrant function of translation initiation factors leads to translation reprogramming that promotes proliferation, survival, angiogenesis, and metastasis. In such context, understanding how altered levels (and presumably activity) of initiation factors can contribute to tumor initiation and/or maintenance is of major interest for the development of novel therapeutic strategies. In this review we provide an overview of translation initiation mechanisms and focus on recent findings describing the role of individual initiation factors and their aberrant activity in cancer.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.06.005