Loading…
The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery
Aim Obstructive sleep apnea syndrome (OSAS) is a common disorder and in subjects with OSAS the prevalence of hypothyroidism is approximately 1.2–11 %. The episodes of hypoxia/reoxygenation associated with the respiratory disturbances observed in subjects with OSAS increases the risk of cardiovascula...
Saved in:
| Published in: | Sleep & breathing 2017-03, Vol.21 (1), p.31-36 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73 |
| container_end_page | 36 |
| container_issue | 1 |
| container_start_page | 31 |
| container_title | Sleep & breathing |
| container_volume | 21 |
| creator | Bozkus, Fulsen Dikmen, Nursel Güngör, Gülay Samur, Anıl |
| description | Aim
Obstructive sleep apnea syndrome (OSAS) is a common disorder and in subjects with OSAS the prevalence of hypothyroidism is approximately 1.2–11 %. The episodes of hypoxia/reoxygenation associated with the respiratory disturbances observed in subjects with OSAS increases the risk of cardiovascular diseases. Hypothyroidism; primary or subclinical, has several effects on cardiovascular system. In our study, we investigated carotid artery intima-media thickness (IMT) which is an early sign of atherosclerosis, in OSAS subjects with hypothyroidism.
Materials and method
Subjects who admitted to Kahramanmaras Necip Fazıl City State Hospital Chest Diseases out-patient clinic between May 2014 and January 2016 for snoring and had polysomnographic evaluation at the sleep laboratory were included in this study. Each subject was evaluated for serum thyroid function tests and carotid artery IMT was measured by a Doppler ultrasound.
Results
Mean carotid artery IMT values in the isolated OSAS, OSAS plus hypothyroidism, and control groups were 0.67 ± 0.12, 0.8 ± 0.12, and 0.54 ± 0.08 mm, respectively; difference between groups was statistically significant (
p
|
| doi_str_mv | 10.1007/s11325-016-1384-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826723477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4319606331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73</originalsourceid><addsrcrecordid>eNp1kctu1TAQhi1ERUvLA7BBltiwMbUncewsUcVNqsSmXVuOM-a4nMTBdpDy9jicghASqxlpvvnn8hPyUvC3gnN1nYVoQDIuOiYa3TJ4Qi6EBGBC8f7pr5yzXgo4J89zfuBctLoXz8g5qLbRCtoLMt0dkKL36AqNnsYhl7S6En4gzUfEhdplRkvzNo8pTkjtPNLDtsRy2FIMY8gTLZGGuYTJsgnHYGk5BPdtxpx3QWdTLGGkNhVM2xU58_aY8cVjvCT3H97f3Xxit18-fr55d8tco6Aw7Z3v7ehl5x30QzsosA6HTgOM9RzeNbLxFp2G0UlpB--UbhXXg-MKJarmkrw56S4pfl8xFzOF7PB4tDPGNRuhoVPQtGpHX_-DPsQ1zXW7SikpBAeASokT5VLMOaE3S6oXp80IbnYvzMkLU70wuxdm73n1qLwO9TN_On4_vwJwAnItzV8x_TX6v6o_AbcglfQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1875110222</pqid></control><display><type>article</type><title>The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery</title><source>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</source><source>Springer Link</source><creator>Bozkus, Fulsen ; Dikmen, Nursel ; Güngör, Gülay ; Samur, Anıl</creator><creatorcontrib>Bozkus, Fulsen ; Dikmen, Nursel ; Güngör, Gülay ; Samur, Anıl</creatorcontrib><description>Aim
Obstructive sleep apnea syndrome (OSAS) is a common disorder and in subjects with OSAS the prevalence of hypothyroidism is approximately 1.2–11 %. The episodes of hypoxia/reoxygenation associated with the respiratory disturbances observed in subjects with OSAS increases the risk of cardiovascular diseases. Hypothyroidism; primary or subclinical, has several effects on cardiovascular system. In our study, we investigated carotid artery intima-media thickness (IMT) which is an early sign of atherosclerosis, in OSAS subjects with hypothyroidism.
Materials and method
Subjects who admitted to Kahramanmaras Necip Fazıl City State Hospital Chest Diseases out-patient clinic between May 2014 and January 2016 for snoring and had polysomnographic evaluation at the sleep laboratory were included in this study. Each subject was evaluated for serum thyroid function tests and carotid artery IMT was measured by a Doppler ultrasound.
Results
Mean carotid artery IMT values in the isolated OSAS, OSAS plus hypothyroidism, and control groups were 0.67 ± 0.12, 0.8 ± 0.12, and 0.54 ± 0.08 mm, respectively; difference between groups was statistically significant (
p
< .05). A poXsitive correlation was found between thyroid stimulating hormone levels and IMT (
r
= 0.426,
p
= .002), while free T3 levels and IMT were negatively correlated (
r
= −0.463,
p
= .001). IMT and apnea-hypopnea index were also positively correlated (
r
= 0.403,
p
= .003).
Conclusion
We suggest, physicians should be alert for hypothyroidism comorbidity in OSAS, and suspected subjects with OSAS should be screened for hypothyroidism considering the potential cardiovascular complications.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-016-1384-2</identifier><identifier>PMID: 27438724</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Carotid arteries ; Carotid Intima-Media Thickness ; Comorbidity ; Dentistry ; Female ; Humans ; Hypothyroidism ; Hypothyroidism - complications ; Hypothyroidism - physiopathology ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Otorhinolaryngology ; Pediatrics ; Pneumology/Respiratory System ; Polysomnography ; Risk Factors ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Sleep Breathing Physiology and Disorders • Original Article ; Ultrasonography, Doppler</subject><ispartof>Sleep & breathing, 2017-03, Vol.21 (1), p.31-36</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Sleep and Breathing is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73</citedby><cites>FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1875110222/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1875110222?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21394,27924,27925,33611,33612,43733,74221</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27438724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bozkus, Fulsen</creatorcontrib><creatorcontrib>Dikmen, Nursel</creatorcontrib><creatorcontrib>Güngör, Gülay</creatorcontrib><creatorcontrib>Samur, Anıl</creatorcontrib><title>The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Aim
Obstructive sleep apnea syndrome (OSAS) is a common disorder and in subjects with OSAS the prevalence of hypothyroidism is approximately 1.2–11 %. The episodes of hypoxia/reoxygenation associated with the respiratory disturbances observed in subjects with OSAS increases the risk of cardiovascular diseases. Hypothyroidism; primary or subclinical, has several effects on cardiovascular system. In our study, we investigated carotid artery intima-media thickness (IMT) which is an early sign of atherosclerosis, in OSAS subjects with hypothyroidism.
Materials and method
Subjects who admitted to Kahramanmaras Necip Fazıl City State Hospital Chest Diseases out-patient clinic between May 2014 and January 2016 for snoring and had polysomnographic evaluation at the sleep laboratory were included in this study. Each subject was evaluated for serum thyroid function tests and carotid artery IMT was measured by a Doppler ultrasound.
Results
Mean carotid artery IMT values in the isolated OSAS, OSAS plus hypothyroidism, and control groups were 0.67 ± 0.12, 0.8 ± 0.12, and 0.54 ± 0.08 mm, respectively; difference between groups was statistically significant (
p
< .05). A poXsitive correlation was found between thyroid stimulating hormone levels and IMT (
r
= 0.426,
p
= .002), while free T3 levels and IMT were negatively correlated (
r
= −0.463,
p
= .001). IMT and apnea-hypopnea index were also positively correlated (
r
= 0.403,
p
= .003).
Conclusion
We suggest, physicians should be alert for hypothyroidism comorbidity in OSAS, and suspected subjects with OSAS should be screened for hypothyroidism considering the potential cardiovascular complications.</description><subject>Adult</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Carotid arteries</subject><subject>Carotid Intima-Media Thickness</subject><subject>Comorbidity</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - physiopathology</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Polysomnography</subject><subject>Risk Factors</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Sleep Breathing Physiology and Disorders • Original Article</subject><subject>Ultrasonography, Doppler</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>M2R</sourceid><recordid>eNp1kctu1TAQhi1ERUvLA7BBltiwMbUncewsUcVNqsSmXVuOM-a4nMTBdpDy9jicghASqxlpvvnn8hPyUvC3gnN1nYVoQDIuOiYa3TJ4Qi6EBGBC8f7pr5yzXgo4J89zfuBctLoXz8g5qLbRCtoLMt0dkKL36AqNnsYhl7S6En4gzUfEhdplRkvzNo8pTkjtPNLDtsRy2FIMY8gTLZGGuYTJsgnHYGk5BPdtxpx3QWdTLGGkNhVM2xU58_aY8cVjvCT3H97f3Xxit18-fr55d8tco6Aw7Z3v7ehl5x30QzsosA6HTgOM9RzeNbLxFp2G0UlpB--UbhXXg-MKJarmkrw56S4pfl8xFzOF7PB4tDPGNRuhoVPQtGpHX_-DPsQ1zXW7SikpBAeASokT5VLMOaE3S6oXp80IbnYvzMkLU70wuxdm73n1qLwO9TN_On4_vwJwAnItzV8x_TX6v6o_AbcglfQ</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Bozkus, Fulsen</creator><creator>Dikmen, Nursel</creator><creator>Güngör, Gülay</creator><creator>Samur, Anıl</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery</title><author>Bozkus, Fulsen ; Dikmen, Nursel ; Güngör, Gülay ; Samur, Anıl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Carotid arteries</topic><topic>Carotid Intima-Media Thickness</topic><topic>Comorbidity</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - physiopathology</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Polysomnography</topic><topic>Risk Factors</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Sleep Breathing Physiology and Disorders • Original Article</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozkus, Fulsen</creatorcontrib><creatorcontrib>Dikmen, Nursel</creatorcontrib><creatorcontrib>Güngör, Gülay</creatorcontrib><creatorcontrib>Samur, Anıl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozkus, Fulsen</au><au>Dikmen, Nursel</au><au>Güngör, Gülay</au><au>Samur, Anıl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>21</volume><issue>1</issue><spage>31</spage><epage>36</epage><pages>31-36</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Aim
Obstructive sleep apnea syndrome (OSAS) is a common disorder and in subjects with OSAS the prevalence of hypothyroidism is approximately 1.2–11 %. The episodes of hypoxia/reoxygenation associated with the respiratory disturbances observed in subjects with OSAS increases the risk of cardiovascular diseases. Hypothyroidism; primary or subclinical, has several effects on cardiovascular system. In our study, we investigated carotid artery intima-media thickness (IMT) which is an early sign of atherosclerosis, in OSAS subjects with hypothyroidism.
Materials and method
Subjects who admitted to Kahramanmaras Necip Fazıl City State Hospital Chest Diseases out-patient clinic between May 2014 and January 2016 for snoring and had polysomnographic evaluation at the sleep laboratory were included in this study. Each subject was evaluated for serum thyroid function tests and carotid artery IMT was measured by a Doppler ultrasound.
Results
Mean carotid artery IMT values in the isolated OSAS, OSAS plus hypothyroidism, and control groups were 0.67 ± 0.12, 0.8 ± 0.12, and 0.54 ± 0.08 mm, respectively; difference between groups was statistically significant (
p
< .05). A poXsitive correlation was found between thyroid stimulating hormone levels and IMT (
r
= 0.426,
p
= .002), while free T3 levels and IMT were negatively correlated (
r
= −0.463,
p
= .001). IMT and apnea-hypopnea index were also positively correlated (
r
= 0.403,
p
= .003).
Conclusion
We suggest, physicians should be alert for hypothyroidism comorbidity in OSAS, and suspected subjects with OSAS should be screened for hypothyroidism considering the potential cardiovascular complications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27438724</pmid><doi>10.1007/s11325-016-1384-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1520-9512 |
| ispartof | Sleep & breathing, 2017-03, Vol.21 (1), p.31-36 |
| issn | 1520-9512 1522-1709 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1826723477 |
| source | Social Science Premium Collection (Proquest) (PQ_SDU_P3); Springer Link |
| subjects | Adult Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Carotid arteries Carotid Intima-Media Thickness Comorbidity Dentistry Female Humans Hypothyroidism Hypothyroidism - complications Hypothyroidism - physiopathology Internal Medicine Male Medicine Medicine & Public Health Middle Aged Neurology Otorhinolaryngology Pediatrics Pneumology/Respiratory System Polysomnography Risk Factors Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Sleep Breathing Physiology and Disorders • Original Article Ultrasonography, Doppler |
| title | The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T10%3A23%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20obstructive%20sleep%20apnea%20syndrome%20and%20hypothyroidism%20to%20intima-media%20thickness%20of%20carotid%20artery&rft.jtitle=Sleep%20&%20breathing&rft.au=Bozkus,%20Fulsen&rft.date=2017-03-01&rft.volume=21&rft.issue=1&rft.spage=31&rft.epage=36&rft.pages=31-36&rft.issn=1520-9512&rft.eissn=1522-1709&rft_id=info:doi/10.1007/s11325-016-1384-2&rft_dat=%3Cproquest_cross%3E4319606331%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-8fcf9adf56fc29b4b72aceb6822d95106353faec82dc55abfc784708bc07e5e73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1875110222&rft_id=info:pmid/27438724&rfr_iscdi=true |