Periostin upregulates the effector functions of eosinophils

Eosinophils were obtained from healthy volunteers or allergic subjects with allergic rhinitis, and their adhesion to periostin or vascular cell adhesion molecule (VCAM)-1 was measured using residual eosinophil peroxidase assays (see this article's Methods section in the Online Repository at www...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-11, Vol.138 (5), p.1449-1452.e5
Main Authors: Noguchi, Toru, MD, Nakagome, Kazuyuki, MD, PhD, Kobayashi, Takehito, MD, PhD, Uchida, Yoshitaka, MD, Soma, Tomoyuki, MD, PhD, Nakamoto, Hidetomo, MD, PhD, Nagata, Makoto, MD, PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Asthma
Cell adhesion & migration
Chemokines
Cytokines
Fibroblasts
Proteins
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Summary:Eosinophils were obtained from healthy volunteers or allergic subjects with allergic rhinitis, and their adhesion to periostin or vascular cell adhesion molecule (VCAM)-1 was measured using residual eosinophil peroxidase assays (see this article's Methods section in the Online Repository at www.jacionline.org). [...]the viability after 48-hour culture was much decreased to about 40% to 60% (Fig E1; 46.6% [without stimulation], 66.8% [+IL-5], or 47.0% [+periostin]). [...]in this study, we incubated eosinophils for 24 hours for cytokine measurement.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.05.020