Neutrophil-Lymphocyte Ratio as a Prognostic Marker for Chemotherapy in Advanced Lung Cancer

Background Lung cancer ranks first both in morbidity and mortality in malignancies, but prognostic biological markers are lacking. The neutrophil-lymphocyte ratio (NLR) was proposed as a convenient biological marker. This study aimed to explore the prognostic value of NLR in advanced non-small cell...

Full description

Saved in:
Bibliographic Details
Published in:The International journal of biological markers 2016-10, Vol.31 (4), p.395-401
Main Authors: Liu, Zhu-Lin, Zeng, Ting-Ting, Zhou, Xiao-Juan, Ren, Ya-Nv, Zhang, Lei, Zhang, Xin-Xing, Ding, Zhen-Yu
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers
Chemotherapy
Cohort Studies
Deoxycytidine - administration & dosage
Deoxycytidine - analogs & derivatives
Female
Humans
Lung cancer
Lung Neoplasms - blood
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Lymphocytes
Lymphocytes - pathology
Male
Medical prognosis
Metastases
Middle Aged
Morbidity
Multivariate analysis
Neutrophils
Neutrophils - pathology
Non-small cell lung carcinoma
Paclitaxel - administration & dosage
Pemetrexed - administration & dosage
Platinum
Prognosis
Retrospective Studies
Small cell lung carcinoma
Survival Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Lung cancer ranks first both in morbidity and mortality in malignancies, but prognostic biological markers are lacking. The neutrophil-lymphocyte ratio (NLR) was proposed as a convenient biological marker. This study aimed to explore the prognostic value of NLR in advanced non-small cell lung cancer (NSCLC). Methods This retrospective study screened patients admitted from October 2007 to October 2014. Patients had histopathologically confirmed, treatment-naïve, metastatic NSCLC, and were prescribed platinum doublet chemotherapy. NLR and demographic data were collected, together with the outcome of chemotherapy. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method and Cox regression model. Results A total of 325 patients were enrolled. The cutoff value for NLR (3.19) was determined by receiver operator characteristic analysis. Patients were dichotomized into high (≥3.19) and low (
ISSN:1724-6008
0393-6155
1724-6008
DOI:10.5301/jbm.5000222