Plasma thiols and thiol-disulfide homeostasis in patients with isolated coronary artery ectasia

• Published in: Atherosclerosis 2016-10, Vol.253, p.209-213
• Main Authors: Kızıltunç, Emrullah, Gök, Murat, Kundi, Harun, Çetin, Mustafa, Topçuoğlu, Canan, Gülkan, Birsen, Çiçekçioğlu, Hülya, Örnek, Ender
• Format: Article
• Language: English
• Subjects: Aged; Cardiovascular; Coronary artery ectasia; Coronary Vessels - pathology; Cross-Sectional Studies; Dilatation, Pathologic - blood; Dilatation, Pathologic - pathology; Disulfides - blood; Female; Homeostasis; Humans; Hypertension; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Sulfhydryl Compounds - blood; Thiol
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2016.07.904

Abstract Background and aims Thiol/disulfide homeostasis has an important role in the antioxidant defense system. Oxidative stress may contribute to the pathogenesis of coronary artery ectasia. The aim of this study was to evaluate plasma thiol levels and thiol/disulfide homeostasis in patients with isolated coronary artery ectasia. Methods Forty-one patients with isolated coronary artery ectasia and 72 patients with normal coronary arteries were included in the study. Markis classification and number of ectatic coronary arteries were recorded. Plasma total thiol levels, native thiol levels and disulfide levels were measured. Thiol/disulfide homeostasis was appraised by calculating thiol/disulfide ratio. Results Plasma native thiol levels were significantly lower (336.9 (252.9–374.1) vs. 353.1 (327.0–380.0), p  = 0.041) and disulfide levels were significantly higher (18.9 ± 6.3 vs. 16.6 ± 3.4, p  = 0.014) in patients with coronary artery ectasia than control patients. Both native thiol/disulfide and total thiol/disulfide ratio was significantly lower in the coronary artery ectasia group ( p