Postoperative Amplitude-Integrated Electroencephalography Predicts Four-Year Neurodevelopmental Outcome in Children with Complex Congenital Heart Disease

• Published in: The Journal of pediatrics 2016-11, Vol.178, p.55-60.e1
• Main Authors: Latal, Beatrice, MD, MPH, Wohlrab, Gabriele, MD, Brotschi, Barbara, MD, Beck, Ingrid, RN, Knirsch, Walter, MD, Bernet, Vera, MD
• Format: Article
• Language: English
• Subjects: background pattern; Brain - growth & development; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - methods; cardiopulmonary bypass; Cardiopulmonary Bypass - methods; Child Development - physiology; Child, Preschool; Cohort Studies; Electroencephalography - methods; Female; Heart Defects, Congenital - surgery; Humans; Infant; Infant, Newborn; Male; Pediatrics; Postoperative Period; Prospective Studies
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2016.06.050

Objectives To evaluate the predictive value of pre- and postoperative amplitude-integrated electroencephalography (aEEG) on neurodevelopmental outcomes in children operated for congenital heart disease (CHD). Study design Prospectively enrolled cohort of 60 infants with CHD who underwent cardiac surgery with cardiopulmonary bypass in the first 3 months of life. Infants with a genetic comorbidity were excluded. aEEG was assessed for 12 hours pre- and 48 hours postoperatively. Background pattern was classified by the use of standard categories, and the presence of seizures and sleep-wake cycles (SWCs) was noted. Outcome at 1 and 4 years of age was assessed with standardized developmental tests. Results Preoperatively, infants either showed continuous normal voltage (n = 56) or discontinuous normal voltage (n = 4). Postoperatively, abnormal background pattern (flat trace, burst suppression, or continuous low voltage) was detected in 7 (12%), discontinuous normal voltage in 37 (61%), and continuous normal voltage in 16 (27%) infants. Nineteen infants (32%) did not return to normal SWCs within the recording period. Seizures were detected in 4 infants preoperatively and in another 4 postoperatively. After we controlled for surgical and postoperative risk factors, abnormal postoperative background pattern and lack of return to SWCs independently predicted poorer intelligence quotient at 4 years ( P  = .03 and P  = .04 respectively) but was not related to motor outcome. Conclusion aEEG is a useful bedside tool that helps to predict outcome in infants undergoing open-heart surgery for CHD. Abnormal postoperative background pattern and lack of return to SWCs are markers for subsequent impaired cognitive development.