The macrophages in testis function

Highlights • Testicular macrophages (TM) comprise the largest leukocyte population in the testis and are M2 polarized. • TM bridge the tasks of maintaining immune privilege and responsiveness to infection by downstream blockade of TLR-4 signaling. • Instead moderate innate immune responses are media...

Full description

Saved in:
Bibliographic Details
Published in:Journal of reproductive immunology 2017-02, Vol.119, p.107-112
Main Authors: Bhushan, Sudhanshu, Meinhardt, Andreas
Format: Article
Language:English
Subjects:
Adult Germline Stem Cells - physiology
Animals
Cell Differentiation
Cytokines - metabolism
Fetal Development
Humans
Immune Privilege
Immunity, Innate
Infection - immunology
Leydig Cells - physiology
Macrophages - immunology
Male
Neovascularization, Physiologic
Obstetrics and Gynecology
Signal Transduction
Steroids - biosynthesis
Testis - immunology
Th2 Cells - immunology
Toll-Like Receptor 4 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Testicular macrophages (TM) comprise the largest leukocyte population in the testis and are M2 polarized. • TM bridge the tasks of maintaining immune privilege and responsiveness to infection by downstream blockade of TLR-4 signaling. • Instead moderate innate immune responses are mediated via MAP kinases and AP-1 and CREB transcription factors. • TM play also important roles in fetal vasculature development, Leydig cell steroidogenesis and spermatogonial stem cell function.
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2016.06.008