One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects

Context: Individuals with glycated hemoglobin (HbA1c)-defined prediabetes (HbA1c value of 5.7–6.4%) and 1-hour plasma glucose ≥155 mg/dL during an oral glucose tolerance test have an increased risk of developing type 2 diabetes. Objective: To evaluate the degree to which HbA1c-defined prediabetes an...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2016-11, Vol.101 (11), p.4030-4038
Main Authors: Fiorentino, Teresa Vanessa, Andreozzi, Francesco, Mannino, Gaia Chiara, Pedace, Elisabetta, Perticone, Maria, Sciacqua, Angela, Perticone, Francesco, Sesti, Giorgio
Format: Article
Language:English
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Summary:Context: Individuals with glycated hemoglobin (HbA1c)-defined prediabetes (HbA1c value of 5.7–6.4%) and 1-hour plasma glucose ≥155 mg/dL during an oral glucose tolerance test have an increased risk of developing type 2 diabetes. Objective: To evaluate the degree to which HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL individually and jointly associate with hepatic steatosis and related biomarkers. Design and Patients: A cross-sectional analysis was performed on 1108 White individuals. Setting: Ambulatory care. Main Outcome Measures: Anthropometric and metabolic characteristics including hepatic steatosis assessed by ultrasonography. Results: Compared with the normal group (HbA1c
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2016-1856