Acute macular neuroretinopathy associated with subclinical cytomegalovirus infection

• Published in: International ophthalmology 2017-06, Vol.37 (3), p.727-731
• Main Authors: Pirani, Vittorio, Cavallero, Edoardo, Mariotti, Cesare, Neri, Piergiorgio, Nicolai, Michele, Cesari, Claudia, Carrozzi, Giulia, Giovannini, Alfonso
• Format: Article
• Language: English
• Subjects: Abnormalities; Acuity; Acute Disease; Adult; Antibodies, Viral - immunology; Case Report; Case reports; Corticosteroids; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus Retinitis - diagnosis; Cytomegalovirus Retinitis - virology; Eye; Eye (anatomy); Eye Infections, Viral - diagnosis; Eye Infections, Viral - virology; Female; Fever; Humans; Immunoglobulin M; Infections; Laboratory tests; Macula Lutea - pathology; Medicine; Medicine & Public Health; Ophthalmology; Serological tests; Thinning; Tomography, Optical Coherence; Urinary tract; Visual Acuity
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-016-0299-z

Purpose To report a case of bilateral acute macular neuroretinopathy (AMN) occurring in a 32-year-old woman, analyzed using the multimodal imaging technique. Case report A 32-year-old Caucasian woman presented with 20 days history of acute onset of blurred vision in the right eye. The best-corrected visual acuity (BCVA) was 0.8 and 1.0 in the right and left eyes, respectively. She reported a lower urinary tract infection associated with fever, 7 days before the onset of the ocular symptoms. Serological tests demonstrated the presence of IgM specific for cytomegalovirus (CMV), while all the other laboratory tests were negative. SD-OCT exhibited the disruption of the inner segment–outer segment junction, associated with hyper-reflectivity of a thickened outer plexiform layer overlying such area associated with thinning of the outer nuclear layer. The patient was diagnosed with AMN and received a corticosteroid treatment. During all the follow-up, OCT features did not change, although BCVA improved. Four months after the first visit, we found also in the left eye a subfoveal IS/OS disruption but differently from the right eye, in which the abnormalities persisted during all the follow-up visits, in the left one they disappeared only after a month. The IgM specific for the CMV remained positive during the whole follow-up. Conclusions To our knowledge, this is the first patient reported with a diagnosis of AMN associated with persisting presence of IgM specific for CMV.