Hesperidin and tiger nut reduced carcinogenicity of DMBA in female rats

Abstract Nutritional studies recommend the regular consumption of fruits and vegetables to favor a healthy quality of life. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the carcinogenic activity of DMBA in female rats. 72 adult Sprague Dawley female rats we...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2016-10, Vol.83, p.718-724
Main Authors: Hamdy, Soha M, Sayed, Ola N, Abdel Latif, Abdel Karim M, Abdel-Aziz, Ayman M, Amin, Alshimaa M
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Body Weight - drug effects
Carcinogenesis - metabolism
Carcinogenesis - pathology
Catalase - metabolism
CEA
Cyperus - chemistry
DMBA
Estradiol
Estradiol - blood
Female
Glutathione Peroxidase - metabolism
Hesperidin
Hesperidin - pharmacology
Hesperidin - therapeutic use
Internal Medicine
Kidney - drug effects
Kidney - pathology
Liver - drug effects
Liver - pathology
Malondialdehyde - blood
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - pathology
Medical Education
N-Acetylneuraminic Acid - blood
Progesterone
Progesterone - blood
Protein Carbonylation - drug effects
Rats, Sprague-Dawley
Superoxide Dismutase - metabolism
Tiger nut
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Summary:Abstract Nutritional studies recommend the regular consumption of fruits and vegetables to favor a healthy quality of life. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the carcinogenic activity of DMBA in female rats. 72 adult Sprague Dawley female rats were divided equally into six groups: control group (I); Hesperidin treated group (II); Tiger Nut treated group (III); DMBA treated group (IV); HES-DMBA treated group (V); and TN-DMBA treated group (VI). There was a significant increase in serum levels of carcinoembryonic antigen, total sialic acid, progesterone, estradiol, ALT, AST, LDH, urea and creatinine, and significant decrease in reduced glutathione level, superoxide dismutase, catalase and glutathione peroxidase activities of DMBA treated group compared to control. In conclusion, our results suggested that supplementation of diets with hesperidin provided antioxidant and chemoprotective activities more significant than tiger nut against the toxicity of DMBA in breast, liver and kidney tissues.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2016.07.032