Surgical conditions during FESS; comparison of dexmedetomidine and remifentanil

• Published in: European archives of oto-rhino-laryngology 2017, Vol.274 (1), p.239-245
• Main Authors: Karabayirli, Safinaz, Ugur, Kadriye Serife, Demircioglu, Ruveyda Irem, Muslu, Bunyamin, Usta, Burhanettin, Sert, Huseyin, Ark, Nebil
• Format: Article
• Language: English
• Subjects: Adult; Blood Loss, Surgical - prevention & control; Dexmedetomidine - therapeutic use; Double-Blind Method; Endoscopy; Female; Follow-Up Studies; Head and Neck Surgery; Humans; Hypnotics and Sedatives - therapeutic use; Hypotension, Controlled - methods; Infusions, Intravenous; Injections, Intravenous; Male; Medicine; Medicine & Public Health; Middle Aged; Nasal Polyps - surgery; Neurosurgery; Otorhinolaryngology; Outcome Assessment (Health Care); Piperidines - therapeutic use; Rhinology
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-016-4220-1

To compare dexmedetomidine with remifentanil in functional endoscopic sinus surgery (FESS) in regards to intra-operative bleeding, anesthetic consumption and post-operative recovery. Randomized, double blind study. Tertiary care medical center. Fifty patients with nasal polyposis who had been scheduled for FESS were randomly divided into two groups. In group D ( n  = 25), dexmedetomidine 1 µg/kg infused intravenous (IV) over 10 min before anesthesia induction, followed by a continuous of 0.7 µg/kg/h infusion during operation. In group R ( n  = 25), 1 µg/kg remifentanil IV bolus, was administered with induction of anesthesia and continued 0.25–0.50 µg/kg/min during operation. Heart rates, mean arterial pressure, end tidal CO 2 , end tidal sevoflurane were recorded. The amount of bleeding, surgical field condition for bleeding and the time to reach Aldrete recovery score 9–10 were recorded. Postoperative nausea, vomiting, pain, shivering, sedation were followed up over 24 h. There was no significant difference between groups according to the amount of bleeding during surgery, assessment of surgical field condition, consumption of sevoflurane, scores of postoperative VAS, rates of nausea and vomiting, shivering, demands of additional analgesic medication ( P  > 0.05). The time to reach Aldrete recovery score 9–10, sedation scores at the postoperative first hour were significantly higher in group D ( P  = 0.001). We concluded that in comparison to remifentanil, dexmedetomidine during FESS for controlled hypotension is of limited value as it has no additional benefits in terms of control of hypotension and amount of bleeding in the surgical field and it is associated with higher recovery time and first-hour postoperative sedation scores.