Suicide behavior as a quantitative trait and its genetic background

• Published in: Journal of affective disorders 2016-12, Vol.206, p.241-250
• Main Authors: Joanna, Pawlak, Monika, Dmitrzak-Weglarz, Monika, Wilkosc, Aleksandra, Szczepankiewicz, Anna, Leszczynska-Rodziewicz, Dorota, Zaremba, Pawel, Kapelski, Aleksandra, Rajewska-Rager, Joanna, Hauser
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Association study; Bipolar Disorder - genetics; Case-Control Studies; Depressive Disorder, Major - genetics; Female; Gene-gene interaction; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide - genetics; Protein Tyrosine Phosphatases - genetics; Proto-Oncogene Proteins - genetics; Psychiatry; Quantitative trait; Receptor, Serotonin, 5-HT2A - genetics; Receptors, Corticotropin-Releasing Hormone - genetics; Serotonin Plasma Membrane Transport Proteins - genetics; Suicidal Ideation; Suicide - psychology; Suicide attempt; Suicide, Attempted - psychology; Tryptophan Hydroxylase - genetics; Young Adult
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2016.07.029

Abstract Introduction Studies have not given yet a clear answer what is the genetic background of suicidal predisposition. The associations between polymorphisms of the TPH1 and 5-HTTLPR genes and violent suicidal behavior was revealed with the least inconsistencies. Method We selected 10 “strong candidate genes” and 35 SNPs, SLC6A4 and ACP1 for replication study. We searched associations between precisely described suicidal phenotype in 825 affective patients and polymorphisms of selected neurobiological pathways genes as well as their interactions that constitute suicidal risk. Results The results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior. Limitations In our study we analyzed limited number of candidate genes and only one of them is linked to lithium mechanism of action. We had no data on pharmacological treatment of investigated patients and its relation to the time of suicide attempt. Conclusion Our results indicate that polymorphisms of various signaling pathways are involved in the pathogenesis of suicidal behavior. Non-genetic factors are also involved in the risk of suicidal attempts.