Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): Dual-energy CT experience in 31 patients

• Published in: European radiology 2017-04, Vol.27 (4), p.1631-1639
• Main Authors: Giordano, Jessica, Khung, Suonita, Duhamel, Alain, Hossein-Foucher, Claude, Bellèvre, Dimitri, Lamblin, Nicolas, Remy, Jacques, Remy-Jardin, Martine
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Angiography - methods; Cardiology; Cardiovascular disease; Chronic Disease; Computed Tomography; Diagnosis, Differential; Diagnostic Radiology; Energy; Female; Hospitals; Humans; Hypertension, Pulmonary - diagnostic imaging; Hypertension, Pulmonary - etiology; Imaging; Internal Medicine; Interventional Radiology; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Neuroradiology; Perfusion Imaging - methods; Pulmonary arteries; Pulmonary Embolism - complications; Pulmonary Embolism - diagnostic imaging; Pulmonary hypertension; Radiology; Scintigraphy; Thromboembolism; Tomography, X-Ray Computed - methods; Ultrasound; Veins & arteries; Ventilation; Young Adult
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-016-4500-6

Purpose To compare lung perfusion in PAH and pCTEPH on dual-energy CT (DECT) examinations. Materials and methods Thirty-one patients with PAH (group 1; n  = 19) and pCTEPH (group 2; n  = 12) underwent a dual-energy chest CTA with reconstruction of diagnostic and perfusion images. Perfusion alterations were analysed at a segmental level. V/Q scintigraphy was available in 22 patients (group 1: 13/19; group 2: 9/12). Results CT perfusion was abnormal in 52.6 % of group 1 patients and in 100 % of group 2 patients ( p  = 0.0051). The patterns of perfusion alteration significantly differed between the two groups ( p