Association between Atrial Fibrillation and Three-Year Mortality in Nondiabetic Patients with Acute First-Ever Ischemic Stroke

Background Diabetes mellitus (DM) is a risk factor for atrial fibrillation (AF) and is known to be an important risk factor for death from stroke. The influence of AF on long-term outcomes in patients with ischemic stroke remains controversial. To clarify the exact influence of AF on stroke outcome...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2016-11, Vol.25 (11), p.2660-2667
Main Authors: Chu, Chun-Hsueh, MD, Weng, Wei-Chieh, MD, Su, Feng-Chieh, MD, Peng, Tsung-I, MD, PhD, Chien, Yu-Yi, MD, Wu, Chia-Lun, MD, Lee, Kuang-Yung, MD, PhD, Wei, Yi-Chia, MD, Lin, Shun-Wen, MD, Yu, Yi-Jing, MD, Huang, Wen-Yi, MD, PhD
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - mortality
Atrial Fibrillation - therapy
Brain Ischemia - diagnosis
Brain Ischemia - mortality
Brain Ischemia - therapy
Cardiovascular
Chi-Square Distribution
Comorbidity
diabetes mellitus
Female
first-ever ischemic stroke
Humans
Kaplan-Meier Estimate
Length of Stay
Logistic Models
Male
Middle Aged
mortality
Multivariate Analysis
Neurology
Prevalence
Proportional Hazards Models
Risk Assessment
Risk Factors
Stroke - diagnosis
Stroke - mortality
Stroke - therapy
stroke outcome
Taiwan - epidemiology
Time Factors
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Summary:Background Diabetes mellitus (DM) is a risk factor for atrial fibrillation (AF) and is known to be an important risk factor for death from stroke. The influence of AF on long-term outcomes in patients with ischemic stroke remains controversial. To clarify the exact influence of AF on stroke outcome and exclude the effect from DM, we investigated the influence of AF on the 3-year outcomes of nondiabetic patients with acute first-ever ischemic stroke. Methods Five-hundred seventy-four nondiabetic patients with acute first-ever ischemic stroke were enrolled and had been followed for 3 years. Patients were divided into 2 groups according to whether AF was diagnosed or not. Clinical presentations, risk factors for stroke, laboratory data, comorbidities, and outcomes were recorded. Results A total of 107 patients (18.6%) had AF. The age was significantly older in patients with AF. Total anterior circulation syndrome occurred more frequently among patients with AF ( P  
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2016.07.012