Antioxidant status of serum bilirubin and uric acid in patients with polymyositis and dermatomyositis

Objective: Oxidative stress and variations in antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with inflammatory cells infiltrating into skeletal muscles, and the antioxidant status is stil...

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Published in:International journal of neuroscience 2017-07, Vol.127 (7), p.617-623
Main Authors: Chen, Zhibo, Su, Zhongqian, Pang, Wanhui, Huang, Yuanyuan, Lin, Jie, Ding, Zhangna, Wu, Senmin, Xu, Shunyao, Quan, Weiwei, Zheng, Juzeng, Chen, Huale, Li, Zhengzheng, Li, Xiang, Li, Jia, Weng, Yiyun, Zhang, Xu
Format: Article
Language:English
Subjects:
Adult
Aged
antioxidant
bilirubin
Bilirubin - blood
dermatomyositis
Dermatomyositis - blood
Female
Humans
Male
Middle Aged
Oxidative Stress - physiology
polymyositis
Polymyositis - blood
uric acid
Uric Acid - blood
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Summary:Objective: Oxidative stress and variations in antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with inflammatory cells infiltrating into skeletal muscles, and the antioxidant status is still controversial. The aim of our study was to investigate the correlation between PM/DM and the antioxidant status of serum bilirubin (Tbil, Dbil and Ibil) and uric acid (UA). Materials and Methods: We measured serum concentrations of bilirubin (Tbil, Dbil and Ibil) and uric acid in 384 individuals, including 110 PM/DM patients and 274 healthy controls. Results: We found that PM/DM patients had significantly lower serum concentrations of bilirubin (Tbil and Ibil) and uric acid than healthy controls, whether male or female. Also, after separately adjusting the covariances of age and gender, Tbil, Dbil, Ibil and UA were all relevant factors for PM/DM. Moreover, there were no significant differences in serum antioxidant molecule levels between PM and DM subgroups. Conclusion: Our study demonstrated the low serum levels of bilirubin and uric acid in patients with PM/DM. This suggested low antioxidant status in PM/DM patients with excessive oxidative stress.
ISSN:0020-7454
1543-5245
1563-5279
DOI:10.1080/00207454.2016.1220380