Breast sarcomas and malignant phyllodes tumours: comparison of clinicopathological features, treatment strategies, prognostic factors and outcomes

We aimed to compare the clinicopathological features, treatment strategies and clinical outcomes of breast sarcomas (BS) and malignant phyllodes tumours (MPT), and determine their prognostic factors. Cases of BS and MPT diagnosed at the Department of Pathology, Singapore General Hospital from Januar...

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Bibliographic Details
Published in:Breast cancer research and treatment 2016-09, Vol.159 (2), p.229-244
Main Authors: Lim, Sue Zann, Selvarajan, Sathiyamoorthy, Thike, Aye Aye, Nasir, Nur Diyana Binte Md, Tan, Benita Kiat Tee, Ong, Kong Wee, Tan, Puay Hoon
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Cancer research
Cancer therapies
Care and treatment
Clinical outcomes
Comparative analysis
Disease-Free Survival
Female
Humans
Medicine
Medicine & Public Health
Oncology
Pathology
Patient outcomes
Phyllodes Tumor - pathology
Phyllodes Tumor - therapy
Preclinical Study
Prognosis
Sarcoma
Sarcoma - pathology
Sarcoma - therapy
Survival Analysis
Tumors
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Summary:We aimed to compare the clinicopathological features, treatment strategies and clinical outcomes of breast sarcomas (BS) and malignant phyllodes tumours (MPT), and determine their prognostic factors. Cases of BS and MPT diagnosed at the Department of Pathology, Singapore General Hospital from January 1991 to December 2014 were derived from department files. Clinicopathological features, treatment strategies and survivals of patients with BS and MPT were compared. Prognostic indicators for BS and MPT were identified. BS and MPT were comparable in all except one of their clinicopathological features. A significantly higher proportion of BS patients had a history of previous breast carcinoma and thus radiation to the chest as compared to the MPT group (17.6 vs 0 %, P  = 0.018). There was no significant difference in survival outcomes between BS and MPT. The 5-year disease-free survivals (DFS) for BS and MPT were 59.1 and 57.4 % respectively ( P  = 0.816), while the 5-year overall survivals (OS) for BS and MPT were 86.5 and 78.5 % respectively ( P  = 0.792). Combining both groups of tumours, univariate analysis showed that DFS was significantly affected by multifocality ( P  = 0.019), histological subtype ( P  = 0.014), presence of malignant heterologous elements ( P  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-016-3946-1