Vitreous biomarkers in diabetic retinopathy: A systematic review and meta-analysis

Abstract The aim of this study was to perform a systematic meta-analysis of biomarkers investigated with diabetic retinopathy (DR) in the vitreous, and to explore the molecular pathway interactions of these markers found to be consistently associated with DR. Relevant databases [PubMed and ISI web o...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2014-05, Vol.28 (3), p.419-425
Main Authors: McAuley, Annie K, Sanfilippo, Paul G, Hewitt, Alex W, Liang, Helena, Lamoureux, Ecosse, Wang, Jie Jin, Connell, Paul P
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers - metabolism
Candidates
Confidence intervals
Diabetes
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - metabolism
Endocrinology & Metabolism
EPO
HGF
Humans
IL-6
IL-8
KEGG pathway
Macular edema
Pathogenesis
Proliferative retinopathy
Proto-Oncogene Proteins c-sis - metabolism
Receptor, Endothelin A - metabolism
Receptor, Endothelin B - metabolism
Standard deviation
Statistical analysis
Studies
Transforming Growth Factor beta - metabolism
Vascular endothelial growth factor
VEGF
Vitrectomy
Vitreous Body - metabolism
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Summary:Abstract The aim of this study was to perform a systematic meta-analysis of biomarkers investigated with diabetic retinopathy (DR) in the vitreous, and to explore the molecular pathway interactions of these markers found to be consistently associated with DR. Relevant databases [PubMed and ISI web of science] were searched for all published articles investigating molecular biomarkers of the vitreous associated with DR. Based on set exclusion/inclusion criteria available data from studies with human vitreous samples were extracted and used for our meta-analysis. The interactions of significant biomarkers in DR were investigated via STRING and KEGG pathway analysis. Our meta-analysis of DR identifies eleven biomarkers as potential therapeutic candidates alternate to current anti-VEGF therapy. Four of these are deemed viable therapeutic targets for PDR; ET receptors (ET A and ET B), anti-PDGF-BB, blocking TGF-β using cell therapy and PEDF. The identification of supplementary or synergistic therapeutic candidates to anti VEGF in the treatment of DR may aid in the development of future treatment trials.
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2013.09.010