Predicting non-diabetic renal disease in type 2 diabetic adults: The value of glycated hemoglobin

• Published in: Journal of diabetes and its complications 2015-07, Vol.29 (5), p.718-723
• Main Authors: Pallayova, Maria, Mohammed, Azharuddin, Langman, Gerald, Taheri, Shahrad, Dasgupta, Indranil
• Format: Article
• Language: English
• Subjects: Aged; Biopsy; Cohort Studies; Confidence intervals; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - pathology; Diabetic Nephropathies - physiopathology; Diabetic retinopathy; Early Diagnosis; Endocrinology & Metabolism; England - epidemiology; Ethnicity; Female; Follow-Up Studies; Glomerular Filtration Rate; Glycated hemoglobin; Glycated Hemoglobin A - analysis; Humans; Kidney - pathology; Kidney - physiopathology; Kidney diseases; Male; Microscopy; Middle Aged; Mortality; Nephritis - complications; Nephritis - diagnosis; Nephritis - epidemiology; Nephritis - pathology; Non-diabetic renal disease; Precision Medicine; Predictive Value of Tests; Prevalence; Renal biopsy; Renal disease; Retrospective Studies; Risk Factors; Sensitivity and Specificity; Studies; Type 2 diabetes mellitus; Up-Regulation; Urine; Variables
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2014.12.005

Abstract Aims The indications for renal biopsy in type 2 diabetes mellitus (T2D) are not well established. We investigated the prevalence, spectrum, and predictors of biopsy-proven non-diabetic renal disease (NDRD) in T2D. Methods An observational, single-center, retrospective study of T2D adults who underwent renal biopsies ( N = 51) over 10 years for nephrotic-range proteinuria, microscopic hematuria, or rapidly declining renal function. Results Thirty-five (68.6%) biopsies were diagnostic of NDRD, and 16 (31.4%) revealed isolated diabetic nephropathy. The most common NDRDs were interstitial nephritis (20%), progressive crescentic glomerulonephritis (14%), membranous nephropathy (11%), and focal segmental glomerulosclerosis (11%). The odds for NDRD declined by 97% in the presence of diabetic retinopathy ( P < 0.001). The deterioration of HbA1c during the year before biopsy predicted NDRD even after adjusting for diabetic retinopathy (OR, 7.65; 95% CI, 1.36–123.04; P = 0.003). A model based on the interaction between the HbA1c values 12 months before biopsy and the absolute change in these values during the preceding year predicted NDRD with 73.7% sensitivity and 75% specificity (AUC, 0.77; 95% CI, 0.59–0.94). Conclusions This study demonstrated a considerably high prevalence of NDRD in T2D adults undergoing renal biopsy. The absence of diabetic retinopathy, lower HbA1c values 12 months before biopsy and greater deterioration in HbA1c prior to biopsy predicted NDRD in T2D. Further studies are needed to validate the findings.