Oxidized low-density lipoprotein antibodies/high-density lipoprotein cholesterol ratio is linked to advanced non-alcoholic fatty liver disease lean patients

Background and Aim A small but significant proportion of patients with normal body mass index show non‐alcoholic fatty liver disease (NAFLD). Oxidized low‐density lipoprotein (LDL) is a powerful immunogenic molecule, which causes oxidative stress and produces antibodies (oxLDL‐ab). We aimed to analy...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2016-09, Vol.31 (9), p.1611-1618
Main Authors: Ampuero, Javier, Ranchal, Isidora, Gallego-Durán, Rocío, Pareja, María Jesús, del Campo, Jose Antonio, Pastor-Ramírez, Helena, Rico, María Carmen, Picón, Rocío, Pastor, Luis, García-Monzón, Carmelo, Andrade, Raúl, Romero-Gómez, Manuel
Format: Article
Language:English
Subjects:
Adult
Anthropometry - methods
Autoantibodies - blood
Biomarkers - blood
Biopsy
Body Mass Index
Cholesterol - blood
Cholesterol, HDL - blood
Cross-Sectional Studies
Female
fibrosis
HDL
Humans
inflammation
Lipoproteins, LDL - immunology
Liver - pathology
Male
Middle Aged
NASH
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - immunology
Non-alcoholic Fatty Liver Disease - pathology
Obesity - blood
Obesity - complications
Obesity - immunology
oxLDL-ab
Severity of Illness Index
Single-Blind Method
steatosis
Thinness - blood
Thinness - complications
Thinness - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Aim A small but significant proportion of patients with normal body mass index show non‐alcoholic fatty liver disease (NAFLD). Oxidized low‐density lipoprotein (LDL) is a powerful immunogenic molecule, which causes oxidative stress and produces antibodies (oxLDL‐ab). We aimed to analyze the role of oxLDL‐ab on histological features in lean‐NAFLD patients. Methods Seventy‐two biopsy‐proven NAFLD patients were included. Lean patients showed body index mass of
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.13335