Dectin-1 agonist selectively induces IgG1 class switching by LPS-activated mouse B cells

Highlights • Dectin-1 agonists selectively enhanced germline γ1 transcription by LPS-activated mouse B cells. • Dectin-1 agonist elevated the number of IgG1-expressing cells and IgG1-secreting cells. • Dectin-1 agonist reinforced LPS-induced B cell activation and surface Dectin-1 expression. • Decti...

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Bibliographic Details
Published in:Immunology letters 2016-10, Vol.178, p.114-121
Main Authors: Seo, Beom-Seok, Park, Ha-Yan, Yoon, Hee-Kyung, Yoo, Yung-Choon, Lee, Junglim, Park, Seok-Rae
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibody Formation - immunology
B cells
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell Membrane - metabolism
Dectin-1
Gene Expression Regulation
Germ Cells - immunology
Germ Cells - metabolism
Germline γ1 transcripts
IgG1
Immunoglobulin Class Switching - genetics
Immunoglobulin Class Switching - immunology
Immunoglobulin G - genetics
Immunoglobulin G - immunology
Lectins, C-Type - agonists
Lectins, C-Type - genetics
Lectins, C-Type - metabolism
Lipopolysaccharides - immunology
LPS
Lymphocyte Activation - genetics
Lymphocyte Activation - immunology
Mice
Saccharomyces cerevisiae
Toll-Like Receptors - agonists
Toll-Like Receptors - metabolism
Transcriptional Activation - immunology
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Summary:Highlights • Dectin-1 agonists selectively enhanced germline γ1 transcription by LPS-activated mouse B cells. • Dectin-1 agonist elevated the number of IgG1-expressing cells and IgG1-secreting cells. • Dectin-1 agonist reinforced LPS-induced B cell activation and surface Dectin-1 expression. • Dectin-1 agonists selectively induced IgG1 production in LPS-stimulated B cells through direct stimulation of B cell Dectin-1.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.08.010