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Dectin-1 agonist selectively induces IgG1 class switching by LPS-activated mouse B cells

Highlights • Dectin-1 agonists selectively enhanced germline γ1 transcription by LPS-activated mouse B cells. • Dectin-1 agonist elevated the number of IgG1-expressing cells and IgG1-secreting cells. • Dectin-1 agonist reinforced LPS-induced B cell activation and surface Dectin-1 expression. • Decti...

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Published in:	Immunology letters 2016-10, Vol.178, p.114-121
Main Authors:	Seo, Beom-Seok, Park, Ha-Yan, Yoon, Hee-Kyung, Yoo, Yung-Choon, Lee, Junglim, Park, Seok-Rae
Format:	Article
Language:	English
Subjects:	Allergy and Immunology Animals Antibody Formation - immunology B cells B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Membrane - metabolism Dectin-1 Gene Expression Regulation Germ Cells - immunology Germ Cells - metabolism Germline γ1 transcripts IgG1 Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology Lectins, C-Type - agonists Lectins, C-Type - genetics Lectins, C-Type - metabolism Lipopolysaccharides - immunology LPS Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Saccharomyces cerevisiae Toll-Like Receptors - agonists Toll-Like Receptors - metabolism Transcriptional Activation - immunology
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container_title	Immunology letters
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creator	Seo, Beom-Seok Park, Ha-Yan Yoon, Hee-Kyung Yoo, Yung-Choon Lee, Junglim Park, Seok-Rae
description	Highlights • Dectin-1 agonists selectively enhanced germline γ1 transcription by LPS-activated mouse B cells. • Dectin-1 agonist elevated the number of IgG1-expressing cells and IgG1-secreting cells. • Dectin-1 agonist reinforced LPS-induced B cell activation and surface Dectin-1 expression. • Dectin-1 agonists selectively induced IgG1 production in LPS-stimulated B cells through direct stimulation of B cell Dectin-1.
doi_str_mv	10.1016/j.imlet.2016.08.010
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source	ScienceDirect Freedom Collection 2022-2024
subjects	Allergy and Immunology Animals Antibody Formation - immunology B cells B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Membrane - metabolism Dectin-1 Gene Expression Regulation Germ Cells - immunology Germ Cells - metabolism Germline γ1 transcripts IgG1 Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology Lectins, C-Type - agonists Lectins, C-Type - genetics Lectins, C-Type - metabolism Lipopolysaccharides - immunology LPS Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Saccharomyces cerevisiae Toll-Like Receptors - agonists Toll-Like Receptors - metabolism Transcriptional Activation - immunology
title	Dectin-1 agonist selectively induces IgG1 class switching by LPS-activated mouse B cells
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