Low serum biotin in Japanese children fed with hydrolysate formula

• Published in: Pediatrics international 2016-09, Vol.58 (9), p.867-871
• Main Authors: Sato, Yasuhiro, Wakabayashi, Kenji, Ogawa, Eishin, Kodama, Hiroko, Mimaki, Masakazu
• Format: Article
• Language: English
• Subjects: Adult; Allergies; Alopecia; Avidin; Baby foods; Biotin; Biotin - blood; Biotin - pharmacokinetics; biotin deficiency; Breast milk; Breastfeeding & lactation; Child, Preschool; Children; Enzyme-linked immunosorbent assay; Female; Food allergies; Health risks; Humans; hydrolysate formula; Infant; Infant Formula - chemistry; Infant Nutritional Physiological Phenomena - physiology; Infant, Newborn; Infants; Japan; Male; Milk; milk allergy; Nutritional Status; Pediatrics; Protein Hydrolysates - administration & dosage; Vitamin B
• ISSN: 1328-8067; 1442-200X
• DOI: 10.1111/ped.12937

Background Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding assay. Methods A commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas. Results The biotin content reached the recommended value in only five formulas. All of the hydrolysate formulas and more than half of the special formulas contained biotin