Incidence, Severity, and Association With Adverse Outcome of Hyponatremia in Children Hospitalized With Heart Failure

Hyponatremia is a common finding in adults hospitalized with heart failure (HF) and is associated with longer hospital stays and increased mortality. The significance of hyponatremia in children with HF is not known. We sought to determine the incidence of hyponatremia and association with clinical...

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Bibliographic Details
Published in:The American journal of cardiology 2016-10, Vol.118 (7), p.1006-1010
Main Authors: Price, Jack F., MD, Kantor, Paul F., MBBCh, Shaddy, Robert E., MD, Rossano, Joseph W., MD, Goldberg, Jason F., MD, Hagan, Joseph, ScD, Humlicek, Timothy J., PharmD, Cabrera, Antonio G., MD, Jeewa, Aamir, MD, Denfield, Susan W., MD, Dreyer, William J., MD, Akcan-Arikan, Ayse, MD
Format: Article
Language:English
Subjects:
Adolescent
Anemia
Cardiomyopathy
Cardiovascular
Child
Child, Preschool
Clinical outcomes
Cohort Studies
Confidence intervals
Databases, Factual
Diuretics
Edema
Extracorporeal Membrane Oxygenation - utilization
Female
Heart failure
Heart Failure - epidemiology
Heart Failure - mortality
Heart Failure - therapy
Heart rate
Heart Transplantation - utilization
Heart-Assist Devices - utilization
Hospitalization
Hospitals
Hospitals, Pediatric
Humans
Hypertension
Hyponatremia - epidemiology
Incidence
Infant
Infant, Newborn
Kidneys
Laboratories
Male
Mortality
Odds Ratio
Patients
Pediatrics
Peptides
Retrospective Studies
Severity of Illness Index
Sodium
Texas - epidemiology
Transplants & implants
Variables
Ventilation
Young Adult
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Summary:Hyponatremia is a common finding in adults hospitalized with heart failure (HF) and is associated with longer hospital stays and increased mortality. The significance of hyponatremia in children with HF is not known. We sought to determine the incidence of hyponatremia and association with clinical outcome in children hospitalized with HF. Admission and inpatient serum sodium concentrations were analyzed in 141 consecutive children hospitalized with acute decompensated HF. Inclusion criteria include patients (age, birth to 21 years) with biventricular hearts who were hospitalized for HF from January 2007 to December 2012. The primary composite end point was death, cardiac transplantation, or the use of mechanical circulatory support (MCS) during hospitalization. Data for 141 patients were included in the analysis. The cohort included 48 patients (34%) with preexisting HF. Mean serum sodium at admission was 136 ± 4 mmol/L (range 124 to 150 mmol/L). Hyponatremia (serum sodium
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.07.014