Meta-Analysis of Perioperative Stroke and Mortality in Transcatheter Aortic Valve Implantation

• Published in: The American journal of cardiology 2016-10, Vol.118 (7), p.1031-1045
• Main Authors: Muralidharan, Aditya, Thiagarajan, Karthy, Van Ham, Raymond, Gleason, Thomas G., Mulukutla, Suresh, Schindler, John T., Jeevanantham, Vinodh, Thirumala, Parthasarathy D.
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Aortic Valve Stenosis - surgery; Bias; Cause of Death; Female; Humans; Incidence; Intraoperative Complications - epidemiology; Intraoperative Complications - mortality; Male; Mortality; Odds Ratio; Perioperative Period; Postoperative Complications - epidemiology; Postoperative Complications - mortality; Quality; Regression Analysis; Statistical analysis; Stroke; Stroke - epidemiology; Stroke - mortality; Studies; Transcatheter Aortic Valve Replacement
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2016.07.011

Transcatheter aortic valve implantation (TAVI) is a rapidly evolving safe method with decreasing incidence of perioperative stroke. There is a void in literature concerning the impact of stroke after TAVI in predicting 30-day stroke-related mortality. The primary aim of this meta-analysis was to determine whether perioperative stroke increases risk of stroke-related mortality after TAVI. Online databases, using relevant keywords, and additional related records were searched to retrieve articles involving TAVI and stroke after TAVI. Data were extracted from the finalized studies and analyzed to generate a summary odds ratio (OR) of stroke-related mortality after TAVI. The stroke rate and stroke-related mortality rate in the total patient population were 3.07% (893 of 29,043) and 12.27% (252 of 2,053), respectively. The all-cause mortality rate was 7.07% (2,053 of 29,043). Summary OR of stroke-related mortality after TAVI was estimated to be 6.45 (95% confidence interval 3.90 to 10.66, p 6 times greater risk of 30-day stroke-related mortality. Transapical TAVI is not associated with increased stroke-related mortality in patients who suffer from perioperative stroke. Preventative measures need to be taken to alleviate the elevated rates of stroke after TAVI and subsequent direct mortality.