Effect of teriparatide treatment on endothelial function, glucose metabolism and inflammation markers in patients with postmenopausal osteoporosis

• Published in: Clinical endocrinology (Oxford) 2016-10, Vol.85 (4), p.556-560
• Main Authors: Celer, Ozgen, Akalın, Aysen, Oztunali, Cigdem
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biomarkers - analysis; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Female; Femur Neck; Fractures, Bone - chemically induced; Glucose - metabolism; Humans; Inflammation - chemically induced; Lumbar Vertebrae; Osteoporosis, Postmenopausal - complications; Osteoporosis, Postmenopausal - drug therapy; Osteoporosis, Postmenopausal - pathology; Prospective Studies; Teriparatide - administration & dosage; Teriparatide - adverse effects
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/cen.13139

Summary Objective Teriparatide, an anabolic agent used in the treatment of postmenopausal osteoporosis, can induce effects similar to primary hyperparathyroidism. Our objective was to evaluate the effects of teriparatide on endothelial functions, glucose metabolism and inflammation markers in patients diagnosed with postmenopausal osteoporosis. Design, patients and measurements This was a single‐centre, single‐arm, 6‐month prospective study. Twenty‐three postmenopausal women over 65 years old with a lumbar spine or femoral neck T‐score of −4·0 or lower and having at least two compression fractures in thoracic or lumbar spine were studied. Low‐dose intermittent teriparatide (20 μg/day) was supplemented with calcium carbonate (1000 mg elemental calcium) and 880 IU cholecalciferol for 6 months. The biochemical parameters for glucose metabolism, inflammation and atherosclerosis were determined. For the assessment of vascular endothelial function, carotid intima‐media thickness (CIMT), brachial artery intima‐media thickness (BIMT), per cent change in flow‐mediated dilation (FMD%) and nitroglycerine‐induced dilations (NID%) were measured on ultrasonography. Results The fasting plasma glucose, homoeostatic model assessment of insulin resistance, fibrinogen, homocysteine and high‐density lipoprotein cholesterol increased significantly with teriparatide treatment (P  0·05); however, FMD% and NID% showed significant decrease after treatment (P