Key role of pancreatic stellate cells in pancreatic cancer

Highlights • Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma of pancreatic cancer. • Weight of evidence to date supports a facilitatory role for PSCs in pancreatic cancer progression. • A multipronged approach involving targeting of cancer cells and reprogrammin...

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Bibliographic Details
Published in:Cancer letters 2016-10, Vol.381 (1), p.194-200
Main Authors: Pothula, Srinivasa P, Xu, Zhihong, Goldstein, David, Pirola, Romano C, Wilson, Jeremy S, Apte, Minoti V
Format: Article
Language:English
Subjects:
Alcohol
Animals
Antineoplastic Agents - therapeutic use
Apoptosis
Cell Communication
Collagen
Desmoplastic reaction
Gene expression
Growth factors
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Ligands
Medical prognosis
Medical research
Metabolites
Molecular Targeted Therapy
Mortality
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Pancreatic stellate cells
Pancreatic Stellate Cells - drug effects
Pancreatic Stellate Cells - metabolism
Pancreatic Stellate Cells - pathology
Patients
Proteins
Signal Transduction
Stromal Cells - drug effects
Stromal Cells - metabolism
Stromal Cells - pathology
Stromal–tumour interactions
Studies
Tumor Microenvironment
Tumors
Tumour microenvironment
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Summary:Highlights • Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma of pancreatic cancer. • Weight of evidence to date supports a facilitatory role for PSCs in pancreatic cancer progression. • A multipronged approach involving targeting of cancer cells and reprogramming of stroma may improve the patient outcome.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.10.035