Lymphedema-associated neutrophilic dermatosis: Two cases of localized Sweet syndrome on the lymphedematous lower limbs

Neutrophilic dermatosis on the site of lymphedema is a rare condition and considered as a localized and less severe variant of Sweet syndrome. Only 13 cases of this variant have been reported after mastectomy for breast cancer in the English‐language published work. However, this condition has never...

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Bibliographic Details
Published in:Journal of dermatology 2016-09, Vol.43 (9), p.1062-1066
Main Authors: Chu, Chien-Ho, Cheng, Yu-Ping, Kao, Hua-Lin, Liang, Cher-Wei, Chan, Jung-Yi, Yu, Yu
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Anti-Bacterial Agents - therapeutic use
Biopsy
C-Reactive Protein - analysis
Cephalosporins - therapeutic use
corticosteroid
Female
Fever - etiology
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Hydrocortisone - administration & dosage
Hydrocortisone - therapeutic use
Hysterectomy - adverse effects
Hysterectomy - methods
immunocompromised
Infusions, Parenteral
Leukocytosis - blood
Lower Extremity
Lymphedema
Lymphedema - etiology
Melanoma - pathology
Melanoma - radiotherapy
Middle Aged
Neoplasm Staging
neutrophilic dermatosis
Neutrophils - pathology
Prednisolone - administration & dosage
Prednisolone - therapeutic use
Radiation therapy
radiotherapy
Radiotherapy - adverse effects
Skin - pathology
Skin diseases
Sweet Syndrome - blood
Sweet Syndrome - diagnosis
Sweet Syndrome - drug therapy
Sweet Syndrome - etiology
Thrombocytopenia - blood
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
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Description
Summary:Neutrophilic dermatosis on the site of lymphedema is a rare condition and considered as a localized and less severe variant of Sweet syndrome. Only 13 cases of this variant have been reported after mastectomy for breast cancer in the English‐language published work. However, this condition has never been described on the lower limbs or from other causes of lymphedema. Herein, we report two cases of localized Sweet syndrome on the lymphedematous lower limbs: one occurred after radical hysterectomy, bilateral pelvic lymph node dissection and radiotherapy for cervical cancer; the other developed after radiotherapy for malignant melanoma on the right groin. Based on clinical and histological features, we suggest the name “lymphedema‐associated neutrophilic dermatosis” for this underrecognized disease entity.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.13379