More on Antimicrobial Resistance, Linezolid, and Treating Special Populations

Linezolid is included in the World Health Organization's compilation of essential medications, especially as an option for the treatment of drug-resistant tuberculosis.12 Two unwanted features of linezolid deserve comment here; they may possibly be interrelated. A second property shared among t...

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Bibliographic Details
Published in:Clinical therapeutics 2016-09, Vol.38 (9), p.1923-1925
Main Author: Shader, Richard I., MD
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Drug dosages
Drug resistance
Infectious diseases
Internal Medicine
Medical Education
Peripheral neuropathy
Pharmaceuticals
Prescription drugs
Staphylococcus infections
Trademarks
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Summary:Linezolid is included in the World Health Organization's compilation of essential medications, especially as an option for the treatment of drug-resistant tuberculosis.12 Two unwanted features of linezolid deserve comment here; they may possibly be interrelated. A second property shared among these drugs (linezolid, isoniazid, iproniazid, and phenelzine) is their ability to inhibit the enzyme monoamine oxidase A. Although these agents vary in the magnitude of their inhibitory strength, they all can cause drug-drug and drug-food interactions by elevating levels of circulating monoamines such as tyramine, epinephrine, norepinephrine, and serotonin.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2016.08.004