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Physiological mechanisms of pulmonary hypertension
Abstract Pulmonary hypertension is usually related to obstruction of pulmonary blood flow at the level of the pulmonary arteries (e.g. pulmonary embolus), pulmonary arterioles (idiopathic pulmonary hypertension), pulmonary veins (pulmonary veno-occlusive disease) or mitral valve (mitral stenosis and...
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| Published in: | The American heart journal 2016-10, Vol.180, p.1-11 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c469t-3dd46ada278e741e796b9b900fb3f94bc5c1926cf2e5c47702a57706836e1ec63 |
| container_end_page | 11 |
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| container_title | The American heart journal |
| container_volume | 180 |
| creator | MacIver, David H Adeniran, Ismail MacIver, Iain R Revell, Alistair Zhang, Henggui |
| description | Abstract Pulmonary hypertension is usually related to obstruction of pulmonary blood flow at the level of the pulmonary arteries (e.g. pulmonary embolus), pulmonary arterioles (idiopathic pulmonary hypertension), pulmonary veins (pulmonary veno-occlusive disease) or mitral valve (mitral stenosis and regurgitation). Pulmonary hypertension is also observed in heart failure due to left ventricle myocardial diseases regardless of the ejection fraction. Pulmonary hypertension is often regarded as a passive response to the obstruction to pulmonary flow. We review established fluid dynamics and physiology and discuss the mechanisms underlying pulmonary hypertension. The important role that the right ventricle plays in the development and maintenance of pulmonary hypertension is discussed. We use principles of thermodynamics and discuss a potential common mechanism for a number of disease states, including pulmonary edema, through adding pressure energy to the pulmonary circulation. |
| doi_str_mv | 10.1016/j.ahj.2016.07.003 |
| format | article |
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Pulmonary hypertension is also observed in heart failure due to left ventricle myocardial diseases regardless of the ejection fraction. Pulmonary hypertension is often regarded as a passive response to the obstruction to pulmonary flow. We review established fluid dynamics and physiology and discuss the mechanisms underlying pulmonary hypertension. The important role that the right ventricle plays in the development and maintenance of pulmonary hypertension is discussed. 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| ispartof | The American heart journal, 2016-10, Vol.180, p.1-11 |
| issn | 0002-8703 1097-6744 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Cardiomyopathy Cardiovascular Disease Edema Flow velocity Fluid mechanics Heart failure Humans Hydrodynamics Hypertension, Pulmonary - physiopathology Navier-Stokes equations Physiology Pulmonary arteries Pulmonary Circulation - physiology Pulmonary hypertension Thermodynamics Veins & arteries |
| title | Physiological mechanisms of pulmonary hypertension |
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