P144, a transforming growth factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines

Highlights • P144, a TGF-β inhibitor peptide, produced antitumor effects over glioblastoma, in vitro and in vivo. • P144 induced an upregulation of SMAD7 and downregulation of SKI through inhibition of the TGF-β pathway. • The results support P144 therapeutic potential as a strategy for the treatmen...

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Bibliographic Details
Published in:Cancer letters 2016-10, Vol.381 (1), p.67-75
Main Authors: Gallo-Oller, Gabriel, Vollmann-Zwerenz, Arabel, Meléndez, Bárbara, Rey, Juan A, Hau, Peter, Dotor, Javier, Castresana, Javier S
Format: Article
Language:English
Subjects:
Animals
Anoikis - drug effects
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Brain Neoplasms - drug therapy
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Cell Line, Tumor
Cell Movement - drug effects
Cell Proliferation - drug effects
Colonies & territories
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Dose-Response Relationship, Drug
Female
Glioblastoma
Glioblastoma - drug therapy
Glioblastoma - genetics
Glioblastoma - metabolism
Glioblastoma - pathology
Growth factors
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Medical prognosis
Melanoma
Mice, Nude
Neoplasm Invasiveness
P144
Peptide Fragments - pharmacology
Peptides
Phosphorylation
Proteins
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Receptors, Transforming Growth Factor beta
Signal Transduction - drug effects
Smad2 Protein - metabolism
Smad7 Protein - genetics
Smad7 Protein - metabolism
Studies
TGF-β inhibition
Time Factors
Transforming Growth Factor beta
Transforming Growth Factor beta - antagonists & inhibitors
Transforming Growth Factor beta - metabolism
Tumor Burden - drug effects
Tumors
Wound healing
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Summary:Highlights • P144, a TGF-β inhibitor peptide, produced antitumor effects over glioblastoma, in vitro and in vivo. • P144 induced an upregulation of SMAD7 and downregulation of SKI through inhibition of the TGF-β pathway. • The results support P144 therapeutic potential as a strategy for the treatment of glioblastoma.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2016.07.029