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The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes
Periodontitis is the most common bone loss pathology in adults and if left untreated is responsible for premature tooth loss. Cytokines, such as tumour necrosis factor‐α (TNFα), involved in the chronic inflammatory response within the periodontal gingiva, significantly influence the normal bone remo...
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Published in: | Journal of periodontal research 2016-10, Vol.51 (5), p.549-566 |
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container_title | Journal of periodontal research |
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creator | Algate, K. Haynes, D. R. Bartold, P. M. Crotti, T. N. Cantley, M. D. |
description | Periodontitis is the most common bone loss pathology in adults and if left untreated is responsible for premature tooth loss. Cytokines, such as tumour necrosis factor‐α (TNFα), involved in the chronic inflammatory response within the periodontal gingiva, significantly influence the normal bone remodelling processes. In this review, the effects of TNFα on bone metabolism in periodontitis are evaluated in relation to its direct and indirect actions on bone cells including osteoclasts, osteoblasts and osteocytes. Evidence published to date suggests a potent catabolic role for TNFα through the stimulation of osteoclastic bone resorption as well as the suppression of osteoblastic bone formation and osteocytic survival. However, the extent and timing of TNFα exposure in vitro and in vivo greatly influences its effect on skeletal cells, with contradictory anabolic activity observed with TNFα in a number of studies. None the less, it is evident that managing the chronic inflammatory response in addition to the deregulated bone metabolism is required to improve periodontal and inflammatory bone loss treatments. |
doi_str_mv | 10.1111/jre.12339 |
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R. ; Bartold, P. M. ; Crotti, T. N. ; Cantley, M. D.</creator><creatorcontrib>Algate, K. ; Haynes, D. R. ; Bartold, P. M. ; Crotti, T. N. ; Cantley, M. D.</creatorcontrib><description>Periodontitis is the most common bone loss pathology in adults and if left untreated is responsible for premature tooth loss. Cytokines, such as tumour necrosis factor‐α (TNFα), involved in the chronic inflammatory response within the periodontal gingiva, significantly influence the normal bone remodelling processes. In this review, the effects of TNFα on bone metabolism in periodontitis are evaluated in relation to its direct and indirect actions on bone cells including osteoclasts, osteoblasts and osteocytes. Evidence published to date suggests a potent catabolic role for TNFα through the stimulation of osteoclastic bone resorption as well as the suppression of osteoblastic bone formation and osteocytic survival. However, the extent and timing of TNFα exposure in vitro and in vivo greatly influences its effect on skeletal cells, with contradictory anabolic activity observed with TNFα in a number of studies. None the less, it is evident that managing the chronic inflammatory response in addition to the deregulated bone metabolism is required to improve periodontal and inflammatory bone loss treatments.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/jre.12339</identifier><identifier>PMID: 26667183</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alveolar Bone Loss - metabolism ; Alveolar Bone Loss - therapy ; Animals ; bone metabolism ; Bone Resorption - metabolism ; Cytokines - metabolism ; Dentistry ; Gingiva - metabolism ; Humans ; inflammation ; Osteoblasts - drug effects ; Osteoblasts - metabolism ; Osteoclasts - drug effects ; Osteoclasts - metabolism ; Osteocytes - drug effects ; Osteocytes - metabolism ; Osteogenesis - drug effects ; periodontitis ; Periodontitis - metabolism ; Periodontium - drug effects ; Periodontium - metabolism ; Tumor Necrosis Factor-alpha - pharmacology ; tumour necrosis factor-α</subject><ispartof>Journal of periodontal research, 2016-10, Vol.51 (5), p.549-566</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5369-c896bb7d5b35441955748ed409230077cafa2faa4c295c13762afc325cbfbbc63</citedby><cites>FETCH-LOGICAL-c5369-c896bb7d5b35441955748ed409230077cafa2faa4c295c13762afc325cbfbbc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26667183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Algate, K.</creatorcontrib><creatorcontrib>Haynes, D. R.</creatorcontrib><creatorcontrib>Bartold, P. M.</creatorcontrib><creatorcontrib>Crotti, T. N.</creatorcontrib><creatorcontrib>Cantley, M. D.</creatorcontrib><title>The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes</title><title>Journal of periodontal research</title><addtitle>J Periodont Res</addtitle><description>Periodontitis is the most common bone loss pathology in adults and if left untreated is responsible for premature tooth loss. Cytokines, such as tumour necrosis factor‐α (TNFα), involved in the chronic inflammatory response within the periodontal gingiva, significantly influence the normal bone remodelling processes. In this review, the effects of TNFα on bone metabolism in periodontitis are evaluated in relation to its direct and indirect actions on bone cells including osteoclasts, osteoblasts and osteocytes. Evidence published to date suggests a potent catabolic role for TNFα through the stimulation of osteoclastic bone resorption as well as the suppression of osteoblastic bone formation and osteocytic survival. However, the extent and timing of TNFα exposure in vitro and in vivo greatly influences its effect on skeletal cells, with contradictory anabolic activity observed with TNFα in a number of studies. None the less, it is evident that managing the chronic inflammatory response in addition to the deregulated bone metabolism is required to improve periodontal and inflammatory bone loss treatments.</description><subject>Alveolar Bone Loss - metabolism</subject><subject>Alveolar Bone Loss - therapy</subject><subject>Animals</subject><subject>bone metabolism</subject><subject>Bone Resorption - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Dentistry</subject><subject>Gingiva - metabolism</subject><subject>Humans</subject><subject>inflammation</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoblasts - metabolism</subject><subject>Osteoclasts - drug effects</subject><subject>Osteoclasts - metabolism</subject><subject>Osteocytes - drug effects</subject><subject>Osteocytes - metabolism</subject><subject>Osteogenesis - drug effects</subject><subject>periodontitis</subject><subject>Periodontitis - metabolism</subject><subject>Periodontium - drug effects</subject><subject>Periodontium - metabolism</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>tumour necrosis factor-α</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkc9OFTEUxhujkSu68AVMl5o40D_TdhpXhiBICCQGo2HTtJ3TODh3em1n0PsKvo0vwjPRy1zYmdBN-53-zpec8yH0mpI9Ws7-VYI9yjjXT9CCSkIqoqR4ihaEMFbxuql30Iucr0jRUunnaIdJKRVt-AL9vfgBGEIAP2YcAx6nZZwSHsCnmLuMg_VjTNXNPxwH7OIA2EPfZ9wN17G_hrY88ApSF9s4jLbHthRjb9PM9jHnDzjmEaLvbR7z-1m4O4Ht0G4_1yPkl-hZsH2GV9t7F339dHhxcFydnh99Pvh4WnnBpa58o6VzqhWOi7qmWghVN9DWRDNOiFLeBsuCtbVnWnjKlWQ2eM6Ed8E5L_kuejv7rlL8NUEezbLLm6nsAHHKhjZMaVIToR-BUtUIRogo6LsZ3SwuJwhmlbqlTWtDidmkZEpK5i6lwr7Z2k5uCe0DeR9LAfZn4HfXw_r_Tubky-G9ZTV3dGWffx46bPpppOJKmG9nR0adHesTffndXPJbygeuGA</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Algate, K.</creator><creator>Haynes, D. 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In this review, the effects of TNFα on bone metabolism in periodontitis are evaluated in relation to its direct and indirect actions on bone cells including osteoclasts, osteoblasts and osteocytes. Evidence published to date suggests a potent catabolic role for TNFα through the stimulation of osteoclastic bone resorption as well as the suppression of osteoblastic bone formation and osteocytic survival. However, the extent and timing of TNFα exposure in vitro and in vivo greatly influences its effect on skeletal cells, with contradictory anabolic activity observed with TNFα in a number of studies. None the less, it is evident that managing the chronic inflammatory response in addition to the deregulated bone metabolism is required to improve periodontal and inflammatory bone loss treatments.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26667183</pmid><doi>10.1111/jre.12339</doi><tpages>18</tpages></addata></record> |
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subjects | Alveolar Bone Loss - metabolism Alveolar Bone Loss - therapy Animals bone metabolism Bone Resorption - metabolism Cytokines - metabolism Dentistry Gingiva - metabolism Humans inflammation Osteoblasts - drug effects Osteoblasts - metabolism Osteoclasts - drug effects Osteoclasts - metabolism Osteocytes - drug effects Osteocytes - metabolism Osteogenesis - drug effects periodontitis Periodontitis - metabolism Periodontium - drug effects Periodontium - metabolism Tumor Necrosis Factor-alpha - pharmacology tumour necrosis factor-α |
title | The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes |
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