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The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes

Periodontitis is the most common bone loss pathology in adults and if left untreated is responsible for premature tooth loss. Cytokines, such as tumour necrosis factor‐α (TNFα), involved in the chronic inflammatory response within the periodontal gingiva, significantly influence the normal bone remo...

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Published in:Journal of periodontal research 2016-10, Vol.51 (5), p.549-566
Main Authors: Algate, K., Haynes, D. R., Bartold, P. M., Crotti, T. N., Cantley, M. D.
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Language:English
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cited_by cdi_FETCH-LOGICAL-c5369-c896bb7d5b35441955748ed409230077cafa2faa4c295c13762afc325cbfbbc63
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container_issue 5
container_start_page 549
container_title Journal of periodontal research
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creator Algate, K.
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description Periodontitis is the most common bone loss pathology in adults and if left untreated is responsible for premature tooth loss. Cytokines, such as tumour necrosis factor‐α (TNFα), involved in the chronic inflammatory response within the periodontal gingiva, significantly influence the normal bone remodelling processes. In this review, the effects of TNFα on bone metabolism in periodontitis are evaluated in relation to its direct and indirect actions on bone cells including osteoclasts, osteoblasts and osteocytes. Evidence published to date suggests a potent catabolic role for TNFα through the stimulation of osteoclastic bone resorption as well as the suppression of osteoblastic bone formation and osteocytic survival. However, the extent and timing of TNFα exposure in vitro and in vivo greatly influences its effect on skeletal cells, with contradictory anabolic activity observed with TNFα in a number of studies. None the less, it is evident that managing the chronic inflammatory response in addition to the deregulated bone metabolism is required to improve periodontal and inflammatory bone loss treatments‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬.
doi_str_mv 10.1111/jre.12339
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subjects Alveolar Bone Loss - metabolism
Alveolar Bone Loss - therapy
Animals
bone metabolism
Bone Resorption - metabolism
Cytokines - metabolism
Dentistry
Gingiva - metabolism
Humans
inflammation
Osteoblasts - drug effects
Osteoblasts - metabolism
Osteoclasts - drug effects
Osteoclasts - metabolism
Osteocytes - drug effects
Osteocytes - metabolism
Osteogenesis - drug effects
periodontitis
Periodontitis - metabolism
Periodontium - drug effects
Periodontium - metabolism
Tumor Necrosis Factor-alpha - pharmacology
tumour necrosis factor-α
title The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes
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