Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2

Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia–reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates...

Full description

Saved in:
Bibliographic Details
Published in:Laboratory investigation 2016-10, Vol.96 (10), p.1087-1104
Main Authors: Meng, Qing-Tao, Cao, Chen, Wu, Yang, Liu, Hui-Min, Li, Wei, Sun, Qian, Chen, Rong, Xiao, Yong-Guang, Tang, Ling-Hua, Jiang, Ying, Leng, Yan, Lei, Shao-Qing, Lee, Chris C, Barry, Devin M, Chen, Xiangdong, Xia, Zhong-Yuan
Format: Article
Language:English
Subjects:
14/28
631/45/881
631/80/86/2366
64/60
96/95
Acute Lung Injury - etiology
Acute Lung Injury - metabolism
Acute Lung Injury - prevention & control
Animals
Glutathione Peroxidase - metabolism
Heme Oxygenase-1 - metabolism
Interleukin-6 - blood
Intestines - blood supply
Ischemic Postconditioning
Laboratory Medicine
Lung - enzymology
Male
Malondialdehyde - metabolism
Medicine
Medicine & Public Health
Membrane Proteins - metabolism
Mice, Inbred C57BL
NF-E2-Related Factor 2 - metabolism
Pathology
Random Allocation
Reperfusion Injury - complications
research-article
Superoxide Dismutase - metabolism
Tumor Necrosis Factor-alpha - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243
cites cdi_FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243
container_end_page 1104
container_issue 10
container_start_page 1087
container_title Laboratory investigation
container_volume 96
creator Meng, Qing-Tao
Cao, Chen
Wu, Yang
Liu, Hui-Min
Li, Wei
Sun, Qian
Chen, Rong
Xiao, Yong-Guang
Tang, Ling-Hua
Jiang, Ying
Leng, Yan
Lei, Shao-Qing
Lee, Chris C
Barry, Devin M
Chen, Xiangdong
Xia, Zhong-Yuan
description Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia–reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.
doi_str_mv 10.1038/labinvest.2016.87
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827904904</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0023683722011795</els_id><sourcerecordid>1823037757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243</originalsourceid><addsrcrecordid>eNqNkc9qFTEUxoMo9lp9ADcScONmrmeSySRXV6VYLRTddD9kMic1l7nJNX8KdeU7-IY-SXOdWsRFEQInJL_vO4fzEfKyhXULXL2d9ej8Naa8ZtD2ayUfkVUrODTAQT4mKwDGm15xeUSepbQFaLuuF0_JEZMCWhCwIt_Pk_mKO2foPqTcmOAnl13wzl9RnTP6ojMmqk3JSOdSX53flnhTy1QMTnQ8XCuSndczdYub_vXjZ8Q9RltSNasErS3wHY1hRhos_Rwte06eWD0nfHFXj8nl2YfL00_NxZeP56cnF40RALnRXArD1STsuFFWWSG06jZyI6XlFtVotJiYEJKBMr3o2AgjQt-JUXJA1vFj8max3cfwrdRBh12dEudZewwlDa1icgNdPf-DcuBSClnR1_-g21BiXcFvivFNJ0BVql0oE0NKEe2wj26n483QwnCIcLiPcDhEOKiD86s75zLucLpX_MmsAmwBUv3yVxj_av2A6_tFhHXT166KknHoa4IuosnDFNwD6ludysFS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1822394508</pqid></control><display><type>article</type><title>Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2</title><source>Nature</source><creator>Meng, Qing-Tao ; Cao, Chen ; Wu, Yang ; Liu, Hui-Min ; Li, Wei ; Sun, Qian ; Chen, Rong ; Xiao, Yong-Guang ; Tang, Ling-Hua ; Jiang, Ying ; Leng, Yan ; Lei, Shao-Qing ; Lee, Chris C ; Barry, Devin M ; Chen, Xiangdong ; Xia, Zhong-Yuan</creator><creatorcontrib>Meng, Qing-Tao ; Cao, Chen ; Wu, Yang ; Liu, Hui-Min ; Li, Wei ; Sun, Qian ; Chen, Rong ; Xiao, Yong-Guang ; Tang, Ling-Hua ; Jiang, Ying ; Leng, Yan ; Lei, Shao-Qing ; Lee, Chris C ; Barry, Devin M ; Chen, Xiangdong ; Xia, Zhong-Yuan</creatorcontrib><description>Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia–reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.</description><identifier>ISSN: 0023-6837</identifier><identifier>EISSN: 1530-0307</identifier><identifier>DOI: 10.1038/labinvest.2016.87</identifier><identifier>PMID: 27501050</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>14/28 ; 631/45/881 ; 631/80/86/2366 ; 64/60 ; 96/95 ; Acute Lung Injury - etiology ; Acute Lung Injury - metabolism ; Acute Lung Injury - prevention &amp; control ; Animals ; Glutathione Peroxidase - metabolism ; Heme Oxygenase-1 - metabolism ; Interleukin-6 - blood ; Intestines - blood supply ; Ischemic Postconditioning ; Laboratory Medicine ; Lung - enzymology ; Male ; Malondialdehyde - metabolism ; Medicine ; Medicine &amp; Public Health ; Membrane Proteins - metabolism ; Mice, Inbred C57BL ; NF-E2-Related Factor 2 - metabolism ; Pathology ; Random Allocation ; Reperfusion Injury - complications ; research-article ; Superoxide Dismutase - metabolism ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Laboratory investigation, 2016-10, Vol.96 (10), p.1087-1104</ispartof><rights>2016 United States &amp; Canadian Academy of Pathology</rights><rights>United States &amp; Canadian Academy of Pathology 2016</rights><rights>Copyright Nature Publishing Group Oct 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243</citedby><cites>FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27501050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Qing-Tao</creatorcontrib><creatorcontrib>Cao, Chen</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Liu, Hui-Min</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Sun, Qian</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Xiao, Yong-Guang</creatorcontrib><creatorcontrib>Tang, Ling-Hua</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Leng, Yan</creatorcontrib><creatorcontrib>Lei, Shao-Qing</creatorcontrib><creatorcontrib>Lee, Chris C</creatorcontrib><creatorcontrib>Barry, Devin M</creatorcontrib><creatorcontrib>Chen, Xiangdong</creatorcontrib><creatorcontrib>Xia, Zhong-Yuan</creatorcontrib><title>Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2</title><title>Laboratory investigation</title><addtitle>Lab Invest</addtitle><addtitle>Lab Invest</addtitle><description>Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia–reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.</description><subject>14/28</subject><subject>631/45/881</subject><subject>631/80/86/2366</subject><subject>64/60</subject><subject>96/95</subject><subject>Acute Lung Injury - etiology</subject><subject>Acute Lung Injury - metabolism</subject><subject>Acute Lung Injury - prevention &amp; control</subject><subject>Animals</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Heme Oxygenase-1 - metabolism</subject><subject>Interleukin-6 - blood</subject><subject>Intestines - blood supply</subject><subject>Ischemic Postconditioning</subject><subject>Laboratory Medicine</subject><subject>Lung - enzymology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice, Inbred C57BL</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Pathology</subject><subject>Random Allocation</subject><subject>Reperfusion Injury - complications</subject><subject>research-article</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0023-6837</issn><issn>1530-0307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkc9qFTEUxoMo9lp9ADcScONmrmeSySRXV6VYLRTddD9kMic1l7nJNX8KdeU7-IY-SXOdWsRFEQInJL_vO4fzEfKyhXULXL2d9ej8Naa8ZtD2ayUfkVUrODTAQT4mKwDGm15xeUSepbQFaLuuF0_JEZMCWhCwIt_Pk_mKO2foPqTcmOAnl13wzl9RnTP6ojMmqk3JSOdSX53flnhTy1QMTnQ8XCuSndczdYub_vXjZ8Q9RltSNasErS3wHY1hRhos_Rwte06eWD0nfHFXj8nl2YfL00_NxZeP56cnF40RALnRXArD1STsuFFWWSG06jZyI6XlFtVotJiYEJKBMr3o2AgjQt-JUXJA1vFj8max3cfwrdRBh12dEudZewwlDa1icgNdPf-DcuBSClnR1_-g21BiXcFvivFNJ0BVql0oE0NKEe2wj26n483QwnCIcLiPcDhEOKiD86s75zLucLpX_MmsAmwBUv3yVxj_av2A6_tFhHXT166KknHoa4IuosnDFNwD6ludysFS</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Meng, Qing-Tao</creator><creator>Cao, Chen</creator><creator>Wu, Yang</creator><creator>Liu, Hui-Min</creator><creator>Li, Wei</creator><creator>Sun, Qian</creator><creator>Chen, Rong</creator><creator>Xiao, Yong-Guang</creator><creator>Tang, Ling-Hua</creator><creator>Jiang, Ying</creator><creator>Leng, Yan</creator><creator>Lei, Shao-Qing</creator><creator>Lee, Chris C</creator><creator>Barry, Devin M</creator><creator>Chen, Xiangdong</creator><creator>Xia, Zhong-Yuan</creator><general>Elsevier Inc</general><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2</title><author>Meng, Qing-Tao ; Cao, Chen ; Wu, Yang ; Liu, Hui-Min ; Li, Wei ; Sun, Qian ; Chen, Rong ; Xiao, Yong-Guang ; Tang, Ling-Hua ; Jiang, Ying ; Leng, Yan ; Lei, Shao-Qing ; Lee, Chris C ; Barry, Devin M ; Chen, Xiangdong ; Xia, Zhong-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>14/28</topic><topic>631/45/881</topic><topic>631/80/86/2366</topic><topic>64/60</topic><topic>96/95</topic><topic>Acute Lung Injury - etiology</topic><topic>Acute Lung Injury - metabolism</topic><topic>Acute Lung Injury - prevention &amp; control</topic><topic>Animals</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>Interleukin-6 - blood</topic><topic>Intestines - blood supply</topic><topic>Ischemic Postconditioning</topic><topic>Laboratory Medicine</topic><topic>Lung - enzymology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice, Inbred C57BL</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Pathology</topic><topic>Random Allocation</topic><topic>Reperfusion Injury - complications</topic><topic>research-article</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Qing-Tao</creatorcontrib><creatorcontrib>Cao, Chen</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Liu, Hui-Min</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Sun, Qian</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Xiao, Yong-Guang</creatorcontrib><creatorcontrib>Tang, Ling-Hua</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Leng, Yan</creatorcontrib><creatorcontrib>Lei, Shao-Qing</creatorcontrib><creatorcontrib>Lee, Chris C</creatorcontrib><creatorcontrib>Barry, Devin M</creatorcontrib><creatorcontrib>Chen, Xiangdong</creatorcontrib><creatorcontrib>Xia, Zhong-Yuan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Qing-Tao</au><au>Cao, Chen</au><au>Wu, Yang</au><au>Liu, Hui-Min</au><au>Li, Wei</au><au>Sun, Qian</au><au>Chen, Rong</au><au>Xiao, Yong-Guang</au><au>Tang, Ling-Hua</au><au>Jiang, Ying</au><au>Leng, Yan</au><au>Lei, Shao-Qing</au><au>Lee, Chris C</au><au>Barry, Devin M</au><au>Chen, Xiangdong</au><au>Xia, Zhong-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2</atitle><jtitle>Laboratory investigation</jtitle><stitle>Lab Invest</stitle><addtitle>Lab Invest</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>96</volume><issue>10</issue><spage>1087</spage><epage>1104</epage><pages>1087-1104</pages><issn>0023-6837</issn><eissn>1530-0307</eissn><abstract>Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia–reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>27501050</pmid><doi>10.1038/labinvest.2016.87</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0023-6837
ispartof Laboratory investigation, 2016-10, Vol.96 (10), p.1087-1104
issn 0023-6837
1530-0307
language eng
recordid cdi_proquest_miscellaneous_1827904904
source Nature
subjects 14/28
631/45/881
631/80/86/2366
64/60
96/95
Acute Lung Injury - etiology
Acute Lung Injury - metabolism
Acute Lung Injury - prevention & control
Animals
Glutathione Peroxidase - metabolism
Heme Oxygenase-1 - metabolism
Interleukin-6 - blood
Intestines - blood supply
Ischemic Postconditioning
Laboratory Medicine
Lung - enzymology
Male
Malondialdehyde - metabolism
Medicine
Medicine & Public Health
Membrane Proteins - metabolism
Mice, Inbred C57BL
NF-E2-Related Factor 2 - metabolism
Pathology
Random Allocation
Reperfusion Injury - complications
research-article
Superoxide Dismutase - metabolism
Tumor Necrosis Factor-alpha - blood
title Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A03%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ischemic%20post-conditioning%20attenuates%20acute%20lung%20injury%20induced%20by%20intestinal%20ischemia%E2%80%93reperfusion%20in%20mice:%20role%20of%20Nrf2&rft.jtitle=Laboratory%20investigation&rft.au=Meng,%20Qing-Tao&rft.date=2016-10-01&rft.volume=96&rft.issue=10&rft.spage=1087&rft.epage=1104&rft.pages=1087-1104&rft.issn=0023-6837&rft.eissn=1530-0307&rft_id=info:doi/10.1038/labinvest.2016.87&rft_dat=%3Cproquest_cross%3E1823037757%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c500t-a375c38d5fb98f8f55a8497977f3fe8bca5d2557208c6542b0be0645b730e243%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1822394508&rft_id=info:pmid/27501050&rfr_iscdi=true