Effects of bicuculline application on the somatosensory responses of secondary vestibular neurons

Highlights • GABA A antagonist application modifies secondary vestibular neurons resting and somatosensory-evoked activity. • Units showing an increased resting discharge can either increase or decrease their somatosensory responsiveness. • In about a third of the neurons, the responsiveness changes...

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Bibliographic Details
Published in:Neuroscience 2016-10, Vol.335, p.122-133
Main Authors: Grasso, C, Li Volsi, G, Cataldo, E, Manzoni, D, Barresi, M
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
activity modulation
Animals
Bicuculline - pharmacology
GABA
GABA antagonist
GABA-A Receptor Antagonists - pharmacology
Male
Neurology
Neurons - drug effects
Neurons - physiology
neurotransmission
Rats, Sprague-Dawley
Receptors, GABA-A - metabolism
Reflex, Vestibulo-Ocular - drug effects
Rotation
somatosensory input
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
vestibular nuclei
Vestibule, Labyrinth - drug effects
Vestibule, Labyrinth - physiology
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Summary:Highlights • GABA A antagonist application modifies secondary vestibular neurons resting and somatosensory-evoked activity. • Units showing an increased resting discharge can either increase or decrease their somatosensory responsiveness. • In about a third of the neurons, the responsiveness changes without modifications in resting discharge. • Occasionally, depression in basal activity and responsiveness can be observed in the same unit. • It is possible that forepaw rotation modulates GABA release at the level of secondary vestibular neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.08.035