Hypoxia in tissue repair and fibrosis

Hypoxia and hypoxia signalling through the transcription factor hypoxia inducible factor-1 (HIF-1), play an important role in normal tissue repair processes. Tissue injury generally produces at least the transient loss of normal vascular perfusion and the resulting hypoxia induces the expression of...

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Bibliographic Details
Published in:Cell and Tissue Research 2016-09, Vol.365 (3), p.553-562
Main Authors: Darby, Ian A., Hewitson, Tim D.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Disease
DNA repair
Fibrosis
Human Genetics
Humans
Hypoxia
Hypoxia - genetics
Hypoxia - pathology
Molecular Medicine
Organ Specificity
Oxygen - metabolism
Proteomics
Review
Tissues
Wound Healing
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Summary:Hypoxia and hypoxia signalling through the transcription factor hypoxia inducible factor-1 (HIF-1), play an important role in normal tissue repair processes. Tissue injury generally produces at least the transient loss of normal vascular perfusion and the resulting hypoxia induces the expression of many genes that allow the tissue to adapt to hypoxia, to start the repair process and, in time, to re-establish oxygen delivery to the tissue. In most cases, transient hypoxia and the activation of the HIF-1 pathway are beneficial and promote the repair process, producing tissue that might not perfectly reform its original architecture but that has its function substantially restored. However, in some cases of chronic injury, chronic hypoxia and pathological repair, the hypoxia pathway might be responsible for driving the process of fibrosis and can lead to excessive scarring and compromised organ function.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-016-2461-3