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Primary rhabdomyosarcoma of the distal femoral diaphysis: a case report and review of the literature

Primary rhabdomyosarcoma of the bone is an extremely rare condition with few examples reported in the literature. We present the case of a 34-year-old male who presented with a lesion in the distal femur with initial imaging features consistent with Ewing sarcoma. Histologically, the lesion consiste...

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Published in:	Skeletal radiology 2016-10, Vol.45 (10), p.1391-1395
Main Authors:	Bressner, Jarred A., McCarthy, Edward F., Fayad, Laura M., Morris, Carol D.
Format:	Article
Language:	English
Subjects:	Adult Care and treatment Case Report Diagnosis, Differential Diaphyses - diagnostic imaging Diaphyses - pathology Femoral Neoplasms - diagnostic imaging Femoral Neoplasms - pathology Humans Imaging Male Medical research Medicine Medicine & Public Health Medicine, Experimental Nuclear Medicine Orthopedics Pathology Radiology Rare Diseases - diagnostic imaging Rare Diseases - pathology Rhabdomyosarcoma - diagnosis Rhabdomyosarcoma - diagnostic imaging Rhabdomyosarcoma - pathology Sarcoma Sarcoma, Ewing - diagnosis Sarcoma, Ewing - pathology Vincristine
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description	Primary rhabdomyosarcoma of the bone is an extremely rare condition with few examples reported in the literature. We present the case of a 34-year-old male who presented with a lesion in the distal femur with initial imaging features consistent with Ewing sarcoma. Histologically, the lesion consisted of atypical pleomorphic polygonal rhabdomyoblasts demonstrating focal desmin and myogenin expression. A diagnosis of pleomorphic rhabdomyosarcoma was rendered. Despite systemic treatment and surgery, this patient experienced a rapidly progressive disease course. We believe this is only the second report in the orthopedic literature of a case of primary pleomorphic rhabdomyosarcoma of the bone. The key imaging, pathologic, and clinical findings are discussed.
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subjects	Adult Care and treatment Case Report Diagnosis, Differential Diaphyses - diagnostic imaging Diaphyses - pathology Femoral Neoplasms - diagnostic imaging Femoral Neoplasms - pathology Humans Imaging Male Medical research Medicine Medicine & Public Health Medicine, Experimental Nuclear Medicine Orthopedics Pathology Radiology Rare Diseases - diagnostic imaging Rare Diseases - pathology Rhabdomyosarcoma - diagnosis Rhabdomyosarcoma - diagnostic imaging Rhabdomyosarcoma - pathology Sarcoma Sarcoma, Ewing - diagnosis Sarcoma, Ewing - pathology Vincristine
title	Primary rhabdomyosarcoma of the distal femoral diaphysis: a case report and review of the literature
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