Sex differences in alcohol consumption and alterations in nucleus accumbens endocannabinoid mRNA in alcohol-dependent rats

Highlights • Alcohol withdrawal is associated with sexually dimorphic alcohol consumption. • Chronic intermittent alcohol results in sexually dimorphic alterations in nucleus accumbens endocannabinoid mRNA. • Estradiol does not influence alcohol consumption in alcohol-dependent ovariectomized female...

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Bibliographic Details
Published in:Neuroscience 2016-10, Vol.335, p.195-206
Main Authors: Henricks, Angela M, Berger, Anthony L, Lugo, Janelle M, Baxter-Potter, Lydia N, Bieniasz, Kennedy V, Craft, Rebecca M, McLaughlin, Ryan J
Format: Article
Language:English
Subjects:
alcohol
Alcohol Drinking - metabolism
Alcohol Drinking - physiopathology
Alcoholism - metabolism
Animals
endocannabinoids
Endocannabinoids - genetics
Ethanol - pharmacology
Female
Male
Neurology
nucleus accumbens
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Rats, Wistar
RNA, Messenger - metabolism
Sex Characteristics
sex-differences
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Summary:Highlights • Alcohol withdrawal is associated with sexually dimorphic alcohol consumption. • Chronic intermittent alcohol results in sexually dimorphic alterations in nucleus accumbens endocannabinoid mRNA. • Estradiol does not influence alcohol consumption in alcohol-dependent ovariectomized female rats. • Estradiol influences nucleus accumbens endocannabinoid mRNA in ovariectomized female rats.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.08.032