Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection

Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few haematological side effects have been reported with oseltamivir. We report herein the case of an unexpected platelet increase in a 46‐year‐old woman with idiopathic thrombocytopenia (ITP) treated wit...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 2016-10, Vol.30 (5), p.483-485
Main Authors: Bigot, Pierre, Auffret, Marine, Gautier, Sophie, Weinborn, Marie, Ettahar, Nicolas‐Kader, Coupé, Patrick
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Blood Platelets - drug effects
Blood Platelets - metabolism
drug induced
Female
Humans
idiopathic thrombocytopenia
influenza
Influenza, Human - blood
Influenza, Human - complications
Influenza, Human - drug therapy
Middle Aged
Neuraminidase - antagonists & inhibitors
oseltamivir
Oseltamivir - pharmacology
Oseltamivir - therapeutic use
platelet count
Platelet Count - methods
Thrombocytopenia - blood
Thrombocytopenia - complications
Thrombocytopenia - drug therapy
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Summary:Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few haematological side effects have been reported with oseltamivir. We report herein the case of an unexpected platelet increase in a 46‐year‐old woman with idiopathic thrombocytopenia (ITP) treated with oseltamivir for influenza. The mechanism may involve the neuraminidase inhibition which decrease platelet surface sialic acid content and reduce their removal by the reticuloendothelial system. Oseltamivir may be responsible for platelet increase especially in patients with ITP.
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12213