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Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection
Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few haematological side effects have been reported with oseltamivir. We report herein the case of an unexpected platelet increase in a 46‐year‐old woman with idiopathic thrombocytopenia (ITP) treated wit...
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| Published in: | Fundamental & clinical pharmacology 2016-10, Vol.30 (5), p.483-485 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3953-7d242850bbcfad6453f223d6a208489fbacd4b781b5896c089cec2fbaba07ced3 |
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| cites | cdi_FETCH-LOGICAL-c3953-7d242850bbcfad6453f223d6a208489fbacd4b781b5896c089cec2fbaba07ced3 |
| container_end_page | 485 |
| container_issue | 5 |
| container_start_page | 483 |
| container_title | Fundamental & clinical pharmacology |
| container_volume | 30 |
| creator | Bigot, Pierre Auffret, Marine Gautier, Sophie Weinborn, Marie Ettahar, Nicolas‐Kader Coupé, Patrick |
| description | Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few haematological side effects have been reported with oseltamivir. We report herein the case of an unexpected platelet increase in a 46‐year‐old woman with idiopathic thrombocytopenia (ITP) treated with oseltamivir for influenza. The mechanism may involve the neuraminidase inhibition which decrease platelet surface sialic acid content and reduce their removal by the reticuloendothelial system. Oseltamivir may be responsible for platelet increase especially in patients with ITP. |
| doi_str_mv | 10.1111/fcp.12213 |
| format | article |
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| identifier | ISSN: 0767-3981 |
| ispartof | Fundamental & clinical pharmacology, 2016-10, Vol.30 (5), p.483-485 |
| issn | 0767-3981 1472-8206 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Blood Platelets - drug effects Blood Platelets - metabolism drug induced Female Humans idiopathic thrombocytopenia influenza Influenza, Human - blood Influenza, Human - complications Influenza, Human - drug therapy Middle Aged Neuraminidase - antagonists & inhibitors oseltamivir Oseltamivir - pharmacology Oseltamivir - therapeutic use platelet count Platelet Count - methods Thrombocytopenia - blood Thrombocytopenia - complications Thrombocytopenia - drug therapy |
| title | Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection |
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