NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

• Published in: Genetics and molecular research 2015-01, Vol.14 (4), p.13968-13980
• Main Authors: Zhang, Q, Fan, H W, Zhang, J Z, Wang, Y M, Xing, H J
• Format: Article
• Language: English
• Subjects: Alleles; Carrier Proteins - genetics; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Human immunodeficiency virus 1; Humans; NLR Family, Pyrin Domain-Containing 3 Protein; Odds Ratio; Polymorphism, Single Nucleotide
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2015.October.29.17

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal. Statistical analysis of data extracted from the selected high quality studies was performed using the Version 12.0 STATA software. A total of 13 case-control studies met our stringent inclusion and exclusion criteria for the present meta-analysis. These 13 high quality studies contained relevant information on 7719 patients with various diseases and 7094 healthy controls. Our meta-analysis results showed that the NLRP3 gene rs35829419 C>A polymorphism was associated with a significantly increased risk of developing multiple diseases in humans under 5 genetic models (all P < 0.05). Data stratification and subgroup analysis based on the disease type revealed that rs35829419 C>A carriers displayed a markedly increase susceptibility to leprosy, colorectal cancer, HIV-1 infection, rheumatoid arthritis, abdominal aortic aneurysms, inflammatory bowel disease, ulcerative colitis, and atopic dermatitis. In summary, our meta-analysis results revealed the first identified strong correlation between the NLRP3 rs35829419 polymorphism and increased susceptibility to various diseases in humans.