Elevated serum homocysteine level in the development of diabetic peripheral neuropathy

The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DP...

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Bibliographic Details
Published in:Genetics and molecular research 2015-11, Vol.14 (4), p.15365-15375
Main Authors: Zheng, L Q, Zhang, H L, Guan, Z H, Hu, M Y, Zhang, T, Ge, S J
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Biomarkers - blood
Case-Control Studies
China
Diabetes Mellitus - blood
Diabetic Neuropathies - blood
Disease Progression
European Continental Ancestry Group
Female
Homocysteine - blood
Humans
Male
Middle Aged
Peripheral Nervous System Diseases - blood
Risk Factors
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Summary:The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, Ovid, PubMed, Web of Science, Wangfang, and China National Knowledge Infrastructure databases. All analyses were performed by using the STATA software, version 12.0 (StataCorp, College Station, TX, USA) and the Comprehensive Meta-analysis 2.0 software (Biostatic Inc., Englewood, NJ, USA). The standardized mean difference (SMD) and 95% confidence interval (95%CI) were further calculated. The electronic literature search identified six articles that included 603 patients with DPN and 687 healthy controls. The pooled SMD of those six studies revealed that increased serum levels of Hcy may be correlated with DPN (SMD = 1.23, 95%CI: 1.09-1.36, P < 0.001). Subgroup analysis according to ethnicity indicated that high serum Hcy levels might be an important risk factor for DPN in both Asian and Caucasian populations (Asians: SMD = 0.62, 95%CI: 0.45-0.79, P < 0.001; Caucasians: SMD = 2.32, 95%CI: 2.10-2.55, P < 0.001; respectively). Elevated serum levels of Hcy indicate the risk of development of DPN in patients, suggesting that Hcy levels could be used as a marker for new therapeutic approaches to DPN.
ISSN:1676-5680
1676-5680
DOI:10.4238/2015.November.30.14