Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis

• Published in: Journal of clinical anesthesia 2016-03, Vol.29, p.65-74
• Main Authors: Hou, Bingzong, MD, Li, Fujing, MS, Ou, Shanshan, MS, Yang, Lukun, MS, Zhou, Shaopeng, MD
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal surgery; Airway Extubation; Anesthesia; Anesthesia & Perioperative Care; Anesthesia Recovery Period; Anesthesia, Inhalation - methods; Anesthetics, Inhalation - pharmacology; Animal cognition; Clinical trials; Confidence intervals; Consciousness - drug effects; Elective Surgical Procedures; Humans; Inhalation; Meta-analysis; Pain Medicine; Postoperative; Randomized Controlled Trials as Topic; Recovery; Studies; Surgery; Time Factors; Xenon; Xenon - pharmacology
• ISSN: 0952-8180; 1873-4529
• DOI: 10.1016/j.jclinane.2015.10.018

Abstract Study objective To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia. Design Systematic review and meta-analysis. Setting Anesthesia for elective surgeries. Patients Systematic review of randomized controlled trials (RCTs) from databases including Medline (1964-2013), the Cochrane Central Register of Controlled Trials (CENTRAL, 1990-2012), and Google Scholar (1966-2013). Interventions Inhalation of xenon or other anesthetics was administered in elective surgery. Measurements Recovery parameters (time to recovery, alertness/sedation scale scores at “eye opening,” bispectral index at “reaction on demand,” time to extubation, and time to orientation). Main results Eleven RCTs (N = 661 patients) met the inclusion criteria. Recovery from xenon anesthesia was significantly faster in terms of the time to eye opening (mean difference [MD], − 4.18 minutes; 95% confidence interval [CI], − 5.03 to − 3.32 minutes; P < .00001), the time to reaction on demand (MD, − 5.35 minutes; 95% CI, − 6.59 to − 4.11 minutes; P < .00001), the time to extubation (MD, − 4.49 minutes; 95% CI, − 5.40 to − 3.58 minutes; P < .00001), and the time to orientation (MD, − 4.99 minutes; 95% CI, − 6.45 to − 3.52 minutes; P < .00001). Conclusions This meta-analysis confirmed that recovery from xenon anesthesia is faster than other inhalation anesthesia.