Different effects of growth hormone and fasting on the induction patterns of two hormone-sensitive lipase genes in red seabream Pagrus major

Highlights • Two red seabream hormone-sensitive lipase genes (HSL1 and HSL2) were cloned. • Ex vivo growth hormone (GH) treatment were performed on liver and adipose tissue. • GH increased HSL phosphorylation and mRNA levels in both tissues. • However, GH and fasting induced two HSL isoform genes in...

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Bibliographic Details
Published in:General and comparative endocrinology 2016-09, Vol.236, p.121-130
Main Authors: Khieokhajonkhet, Anurak, Kaneko, Gen, Hirano, Yuki, Wang, Lu, Ushio, Hideki
Format: Article
Language:English
Subjects:
Adipose tissue
Animals
Endocrinology & Metabolism
Fasting - metabolism
Fatty Acids, Nonesterified - metabolism
Growth Hormone - metabolism
Lipolysis
Lipolysis - drug effects
Liver
Liver - metabolism
Marine
Non-esterified fatty acid
Pagrus major
Sea Bream - genetics
Sea Bream - metabolism
Teleostei
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Summary:Highlights • Two red seabream hormone-sensitive lipase genes (HSL1 and HSL2) were cloned. • Ex vivo growth hormone (GH) treatment were performed on liver and adipose tissue. • GH increased HSL phosphorylation and mRNA levels in both tissues. • However, GH and fasting induced two HSL isoform genes in different manners in vivo. • Other hormone(s) may contribute to fasting-induced HSL up-regulation under fasting.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2016.06.025