Expression of CD44 variant isoforms, CD44v3 and CD44v6, are associated with prognosis in nasopharyngeal carcinoma

The clinical and prognostic significance of CD44 variant isoform expression in nasopharyngeal carcinoma is not well known. This study aimed to clarify whether CD44 variant isoform expression serves as a prognostic factor in nasopharyngeal carcinoma. Forty-two nasopharyngeal carcinoma patients, who u...

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Bibliographic Details
Published in:Journal of laryngology and otology 2016-09, Vol.130 (9), p.843-849
Main Authors: Sagawa, K, Uwa, N, Daimon, T, Sakagami, M, Tsujimura, T
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Cancer therapies
Chemoradiotherapy - methods
Clinical outcomes
Cloning
Extracellular matrix
Female
Humans
Hyaluronan Receptors - metabolism
Lymphatic system
Main Articles
Male
Medical prognosis
Metastasis
Middle Aged
Nasopharyngeal Neoplasms - diagnosis
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - therapy
Prognosis
Radiation
Survival Analysis
Tomography
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Summary:The clinical and prognostic significance of CD44 variant isoform expression in nasopharyngeal carcinoma is not well known. This study aimed to clarify whether CD44 variant isoform expression serves as a prognostic factor in nasopharyngeal carcinoma. Forty-two nasopharyngeal carcinoma patients, who underwent concurrent chemoradiotherapy as the initial treatment, were the subjects of investigation. Expression of CD44 variant isoforms, CD44v3, CD44v4, CD44v5, CD44v6 and CD44v7, in nasopharyngeal carcinoma was assessed in relation to concurrent chemoradiotherapy resistance and disease-specific survival of the patients. The patients with CD44v6 high expression showed a clinically incomplete response to concurrent chemoradiotherapy at the primary site. The disease-specific survival rate was lower in patients with high expression of CD44v3 than in those with low expression. These results suggest that analysis of CD44v6 and CD44v3 expression is useful in estimating prognosis and determining effective treatment strategies in nasopharyngeal carcinoma.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215116008525